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Fluoroimmunoassay: present status and key problems.
Abstract
Fluorescence immunoassay of biological fluids (for example, blood samples) is discussed. We attempt to chart present methods of assay as well as new possibilities. Different fluorescent probes, their detection limit, and methods for reduction of background are discussed; methods for separating the free and bound fraction are also reviewed. Special consideration is given to the possibilities of enhancing sensitivity by developing both instruments and chemical methods, and in particular to the possibilities inherent in time-resolved fluorometric applications and to the use of metal chelates in this application.
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Citations
Cited by
Gruenberg, J., Griffiths, G., & Howell, K. E. (1989) · The Journal of cell biology · doi:10.1083/jcb.108.4.1301 · Cited by 587
Dynamically Analyte-Responsive Macrocyclic Host–Fluorophore Systems
Ghale, G., & Nau, W. M. (2014) · Accounts of Chemical Research · doi:10.1021/ar500116d · Cited by 361
Sanal, M. G. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i21.6427 · Cited by 10
Metadata
- Authors
- Soini, E., & Hemmilä, I.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1979-03-01
- Volume
- 25
- Issue
- 3
- Pages
- 353-361
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2114761451
- Cited by
- 429
- References
- 0
- FWCI
- 6.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Fluoroimmunoassay: present status and key problems. https://app.cochat.ai/papers/10.1093/clinchem/25.3.353
- The paper
- Soini, E., & Hemmilä, I. (1979). Fluoroimmunoassay: present status and key problems. Clinical Chemistry. https://doi.org/10.1093/clinchem/25.3.353
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
