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Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia.
Abstract
We have developed a highly sensitive, two-site immunoradiometric assay (IRMA) for human parathyrin (PTH) that is specific for the intact, secreted, biologically active 84-amino-acid peptide. This assay has several technical advantages: it does not detect even high concentrations of inactive carboxyl-terminal fragments, results are available within 24 h, and the detection limit for intact hormone is low (1 ng/L). The assay readily measures concentrations of PTH in all healthy subjects and distinguishes these values from low or undetectable PTH values observed in clinical situations in which PTH secretion is expected to be suppressed. We found complete separation of results from 37 patients with surgically proven hyperparathyroidism and those from 23 patients with hypercalcemia associated with malignancy, the latter having PTH values at or below the lower limits of normal for this assay. The sensitivity, specificity, and rapid turnaround time of this two-site IRMA should advance the laboratory evaluation of patients with disorders of calcium metabolism.
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Cited by
Fibroblast Growth Factor 23 in Oncogenic Osteomalacia and X-Linked Hypophosphatemia
Jonsson, K. B., Zahradnik, R., Larsson, T., White, K. E., Sugimoto, T., Imanishi, Y., Yamamoto, T., Hampson, G., Koshiyama, H., Ljunggren, Ö., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020881 · Cited by 914
Self-citationSilverberg, S. J., Lewiecki, E. M., Mosekilde, L., Peacock, M., & Rubin, M. R. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1760 · Cited by 688
Rubin, M. R., Bilezikian, J. P., McMahon, D. J., Jacobs, T., Shane, E., Siris, E., Udesky, J., & Silverberg, S. J. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1215 · Cited by 593
Lepage, R., Roy, L., Brossard, J.-H., Rousseau, L., Dorais, C., Lazure, C., & D’Amour, P. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.4.805 · Cited by 362
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Shane, E., Mancini, D., Aaronson, K., Silverberg, S. J., Seibel, M. J., Addesso, V., & McMahon, D. J. (1997) · The American Journal of Medicine · doi:10.1016/s0002-9343(97)00142-3 · Cited by 358
Metadata
- Authors
- Nussbaum, S. R., Zahradnik, R. J., Lavigne, J. R., Brennan, G. L., Nozawa-Ung, K., Kim, L. Y., Keutmann, H. T., Wang, C. A., Potts, J. T., & Segre, G. V.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1987-08-01
- Volume
- 33
- Issue
- 8
- Pages
- 1364-1367
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2134792323
- Cited by
- 808
- References
- 0
- FWCI
- 30.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia. https://app.cochat.ai/papers/10.1093/clinchem/33.8.1364
- The paper
- Nussbaum, S. R., Zahradnik, R. J., Lavigne, J. R., Brennan, G. L., Nozawa-Ung, K., Kim, L. Y., Keutmann, H. T., Wang, C. A., Potts, J. T., & Segre, G. V. (1987). Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia. Clinical Chemistry. https://doi.org/10.1093/clinchem/33.8.1364
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