The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Serum Creatinine as an Index of Renal Function: New Insights into Old Concepts
Abstract
The serum creatinine concentration is widely interpreted as a measure of the glomerular filtration rate (GFR) and is used as an index of renal function in clinical practice. Glomerular filtration of creatinine, however, is only one of the variables that determines its concentration in serum. Alterations in renal handling and metabolism of creatinine and methodological interferences in its measurement may have a profound impact on the serum concentration of creatinine. We review the fundamental principles of physiology, metabolism, and analytical chemistry that are necessary to correctly interpret the serum creatinine concentration. These principles are then applied to important clinical circumstances, including aging, pregnancy, diabetes mellitus, drug administration, and acute and chronic renal failure. Despite numerous limitations, serum creatinine remains a useful clinical tool, but more accurate measures of renal function are frequently necessary.
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Citations
Cites
Focal and segmental glomerulosclerosis: Analogies to atherosclerosis
Diamond, J. R., & Karnovsky, M. J. (1988) · Kidney International · doi:10.1038/ki.1988.87 · Cited by 330
Cited by
A New Equation to Estimate Glomerular Filtration Rate
Levey, A. S., Stevens, L. A., Schmid, C. H., Zhang, Y. (., Castro, A. F., Feldman, H. I., Kusek, J. W., Eggers, P., Van Lente, F., Greene, T., et al. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-9-200905050-00006 · Cited by 25,603
Self-citationLevey, A. S., Bosch, J. P., Lewis, J. B., Greene, T., Rogers, N., Roth, D., & for the Modification of Diet in Renal Disease Study Group* (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-6-199903160-00002 · Cited by 15,079
Self-citationLevey, A. S., Coresh, J., Balk, E., Kausz, A. T., Levin, A., Steffes, M. W., Hogg, R. J., Perrone, R. D., Lau, J., & Eknoyan, G. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-2-200307150-00013 · Cited by 4,615
Self-citationCreatine and Creatinine Metabolism
Wyss, M., & Kaddurah-Daouk, R. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.1107 · Cited by 2,950
Coresh, J., Astor, B. C., Greene, T., Eknoyan, G., & Levey, A. S. (2003) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2003.50007 · Cited by 2,768
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Metadata
- Authors
- Perrone, R. D., Madias, N. E., & Levey, A. S.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1992-10-01
- Volume
- 38
- Issue
- 10
- Pages
- 1933-1953
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2141348928
- Cited by
- 1,581
- References
- 1
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Serum Creatinine as an Index of Renal Function: New Insights into Old Concepts. https://app.cochat.ai/papers/10.1093/clinchem/38.10.1933
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- Perrone, R. D., Madias, N. E., & Levey, A. S. (1992). Serum Creatinine as an Index of Renal Function: New Insights into Old Concepts. Clinical Chemistry. https://doi.org/10.1093/clinchem/38.10.1933
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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