The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Carbohydrate-deficient transferrin quantified by HPLC to determine heavy consumption of alcohol
Abstract
We developed a new fully automated ion-exchange chromatographic method for quantitating carbohydrate-deficient transferrin (CDT) on a Mono Q column. Quantitation relies on the selective absorbance of the iron-transferrin complex at 460 nm. Transferrin isoforms deficient in sialic acid, with pIs 5.7 and 5.9, can easily be separated and quantitated as a percentage of the total transferrin. This method has been applied to samples from teetotalers, occasional drinkers, patients with recent heavy alcohol consumption, and patients during detoxification. The sensitivity of the method was 55% in patients reporting 40-70 g daily ethanol consumption and nearly 100% in heavily intoxicated patients (70-500 g daily consumption). The half-life of the dominating pI 5.7 isoform in this group was 9.5 (+/- 1) days during detoxification. A CDT value > 0.8% is a highly specific marker for alcohol abuse and is greatly superior to other currently available biological markers.
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Citations
Cites
Wallace, P., Cutler, S., & Haines, A. (1988) · BMJ · doi:10.1136/bmj.297.6649.663 · Cited by 648
Cited by
Arndt, T. (2001) · Clinical Chemistry · doi:10.1093/clinchem/47.1.13 · Cited by 305
Metadata
- Authors
- Jeppsson, J. O., Kristensson, H., & Fimiani, C.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-10-01
- Volume
- 39
- Issue
- 10
- Pages
- 2115-2120
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2119712688
- Cited by
- 177
- References
- 1
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jeppsson, J. O., Kristensson, H., & Fimiani, C. (1993). Carbohydrate-deficient transferrin quantified by HPLC to determine heavy consumption of alcohol. Clinical Chemistry. https://doi.org/10.1093/clinchem/39.10.2115
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
