The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Serum bilirubin and risk of ischemic heart disease in middle-aged British men
Abstract
The possibility that low concentrations of serum bilirubin may be associated with increased risk of ischemic heart disease has been examined in a prospective study of 7685 middle-aged British men. During 11.5 years there were 737 major ischemic heart disease (IHD) events. A U-shaped relationship was observed between serum bilirubin and risk of IHD. Low bilirubin was associated with several cardiovascular risk factors, in particular smoking, low concentrations of high-density lipoprotein cholesterol, low forced expiratory volume in 1 s, and low serum albumin. The U-shaped relationship persisted even after adjusting for several risk factors. Compared with men in the lowest fifth of the distribution (bilirubin < 7 mumol/L), those in the middle range (8-9 mumol/L) showed a 30% reduction in relative risk [RR = 0.68 (95% confidence intervals 0.51-0.89)] in IHD, whereas men in the top fifth (> 12 mumol/L) showed similar risk to the lowest fifth [RR = 0.99 (95% confidence intervals 0.73-1.34)], which persisted after exclusion of men with bilirubin > 17 mumol/L. The significance of this U-shaped relationship is unclear, but it could be interpreted as support for the role of endogenous antioxidants in the etiology of IHD.
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Citations
Cites
ALCOHOL AND MORTALITY IN BRITISH MEN: EXPLAINING THE U-SHAPED CURVE
Shaper, A. G., Wannamethee, G., & Walker, M. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92890-5 · Cited by 780 · cited 1×
“Men were classified into five groups on the basis of their estimated weekly intake: none, occasional, light, moderate, and heavy (18).”
BackgroundSelf-citationObserver bias in blood pressure studies
Bruce, N. G., Shaper, A. G., Walker, M., & Wannamethee, G. (1988) · Journal of Hypertension · doi:10.1097/00004872-198805000-00006 · Cited by 144
Self-citation
Cited by
Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications
Ryter, S. W., Alam, J., & Choi, A. M. K. (2006) · Physiological Reviews · doi:10.1152/physrev.00011.2005 · Cited by 2,307
Bilirubin Benefits: Cellular Protection by a Biliverdin Reductase Antioxidant Cycle
Sedlak, T. W., & Snyder, S. H. (2004) · Pediatrics · doi:10.1542/peds.113.6.1776 · Cited by 440
Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation
Ryter, S. W., & Choi, A. M. K. (2016) · Translational Research · doi:10.1016/j.trsl.2015.06.011 · Cited by 362
Novotný, L., & Vítek, L. (2003) · Experimental Biology and Medicine · doi:10.1177/15353702-0322805-29 · Cited by 347
Lin, J.-P., O’Donnell, C. J., Schwaiger, J. P., Cupples, L. A., Lingenhel, A., Hunt, S. C., Yang, S., & Kronenberg, F. (2006) · Circulation · doi:10.1161/circulationaha.106.633206 · Cited by 314
Metadata
- Authors
- Breimer, L. H., Wannamethee, G., Ebrahim, S., & Shaper, A. G.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-10-01
- Volume
- 41
- Issue
- 10
- Pages
- 1504-1508
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2108870749
- Cited by
- 229
- References
- 2
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Breimer, L. H., Wannamethee, G., Ebrahim, S., & Shaper, A. G. (1995). Serum bilirubin and risk of ischemic heart disease in middle-aged British men. Clinical Chemistry. https://doi.org/10.1093/clinchem/41.10.1504
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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