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Immunoreactive elastase I: clinical evaluation of a new noninvasive test of pancreatic function
Abstract
We have evaluated the diagnostic value of the fecal elastase test in comparison with the secretin-pancreozymin test in the diagnosis of exocrine pancreatic insufficiency. Pancreatic elastase was measured immunologically. Immunoreactive elastase activity in spot stools from controls ranged from 136 to 4440 microgram/g; 95% of all values were within 175 to 1500 microgram/g. The elastase assay CVs ranged from 3.3% to 6.3% (intraassay) and from 4.1% to 10.2% (interassay). The output of elastase correlated well with those of amylase, lipase, and trypsin, yielding respective correlation coefficients of 0.83, 0.82, and 0.84 in controls and 0.86, 0.91, and 0.91 in patients with impaired pancreatic function. In contrast to fecal chymotrypsin, the test results were unaffected by pancreatic enzyme replacement therapy. These results indicate that fecal immunoreactive elastase may be recommended as a new, noninvasive tubeless test of pancreatic function.
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Cited by
Faecal elastase 1: a novel, highly sensitive, and specific tubeless pancreatic function test.
Löser, C., Möllgaard, A., & Fölsch, U. R. (1996) · Gut · doi:10.1136/gut.39.4.580 · Cited by 554
Some Patients With Irritable Bowel Syndrome May Have Exocrine Pancreatic Insufficiency
Leeds, J. S., Hopper, A. D., Sidhu, R., Simmonette, A., Azadbakht, N., Hoggard, N., Morley, S., & Sanders, D. S. (2010) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2009.09.032 · Cited by 109
Metadata
- Authors
- Stein, J., Jung, M., Sziegoleit, A., Zeuzem, S., Caspary, W. F., & Lembcke, B.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-02-01
- Volume
- 42
- Issue
- 2
- Pages
- 222-226
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W1921774856
- Cited by
- 229
- References
- 0
- FWCI
- 10.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Immunoreactive elastase I: clinical evaluation of a new noninvasive test of pancreatic function. https://app.cochat.ai/papers/10.1093/clinchem/42.2.222
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- Stein, J., Jung, M., Sziegoleit, A., Zeuzem, S., Caspary, W. F., & Lembcke, B. (1996). Immunoreactive elastase I: clinical evaluation of a new noninvasive test of pancreatic function. Clinical Chemistry. https://doi.org/10.1093/clinchem/42.2.222
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
