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Human Leishmaniasis: Clinical, Diagnostic, and Chemotherapeutic Developments in the Last 10 Years
Abstract
The current interest in leishmaniasis stems from the importance of this disease with respect to travel medicine, veterans of Operation Desert Storm, humanitarian concerns, and infection with human immunodeficiency virus. Herein, I review aspects of leishmaniasis that are of practical value to practitioners, including presentation, diagnosis, and chemotherapy; I will emphasize advances in chemotherapy over the last 10 years. Amphotericin B and its new lipid formulations are now competitive with pentavalent antimony as primary therapy for visceral leishmaniasis. Pentamidine, paromomycin, and adjunctive therapy with interferon-gamma are secondary regimens for the treatment of this condition. High-dose long-term regimens of antimony have been shown to be highly effective for the treatment of cutaneous leishmaniasis. Preliminary evidence of efficacy has been observed with short courses of pentamidine for the treatment of Leishmania braziliensis complex disease and topical paromomycin/methylbenzethonium chloride for the treatment of Leishmania major disease.
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Cited by
Leishmania infections: Molecular targets and diagnosis
Akhoundi, M., Downing, T., Votýpka, J., Kuhls, K., Lukeš, J., Cannet, A., Ravel, C., Marty, P., Delaunay, P., Kasbari, M., et al. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.11.012 · Cited by 363
Sato, S., St‐Pierre, C., Bhaumik, P., & Nieminen, J. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00790.x · Cited by 299
Roberts, C. W., McLeod, R., Rice, D. W., Ginger, M., Chance, M. L., & Goad, L. J. (2003) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(02)00280-3 · Cited by 296
Meyerhoff, A. (1999) · Clinical Infectious Diseases · doi:10.1086/515085 · Cited by 295
Leishmania requires Rab7-mediated degradation of endocytosed hemoglobin for their growth
Patel, N., Singh, S. B., Basu, S. K., & Mukhopadhyay, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800404105 · Cited by 56
Metadata
- Authors
- Berman, J. D.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-04-01
- Volume
- 24
- Issue
- 4
- Pages
- 684-703
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2168946125
- Cited by
- 806
- References
- 0
- FWCI
- 43.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Berman, J. D. (1997). Human Leishmaniasis: Clinical, Diagnostic, and Chemotherapeutic Developments in the Last 10 Years. Clinical Infectious Diseases. https://doi.org/10.1093/clind/24.4.684
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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