The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Immunoglobulin prophylaxis for hepatitis A.
Abstract
Studies conducted over the past 45 years have shown that immunoglobulin (IG) prevents 80%-90% of cases of hepatitis A when administered before exposure or shortly thereafter. Protection is short lived and requires early diagnosis and timely administration of IG to contacts. Inactivated and attenuated hepatitis A virus (HAV) vaccines have recently been developed and should be available for clinical use within the next few years. Evaluation of antibodies to HAV in IG and in IG recipients provides one method of determining the immunogenicity of HAV vaccines. The role of IG in the prevention of hepatitis A is reviewed with emphasis on the relationship of antibody response following IG administration to the efficacy of HAV vaccines.
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“When administered IM <2 weeks after exposure to HAV, IG is >85% effective in preventing HAV infection (1308).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1308]
Citations
Cites
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Hepatitis A virus antibody levels in factor VIII concentrates
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“Passive immunization with polyclonal serum IG prior to exposure has been available since the 1940s and has been shown to decrease the incidence of HAV infection by more than 90% (163).”
InfluentialKoff, R. S. (2004) · doi:10.1007/978-1-4615-6502-4_2 · Cited by 1
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Rashidi, A., Sedaghat, F., Nejat, A., Azarpira, N., Shamsaeefar, A., Kazemi, K., & Moini, M. (2021) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2021.03.008
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Forebygging av sekundærtilfeller av hepatitt A- er gammaglobulin eller vaksine best egnet?
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Metadata
- Authors
- Winokur, P. L., & Stapleton, J. T.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Stapleton, J. T.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1992-02-01
- Volume
- 14
- Issue
- 2
- Pages
- 580-586
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2017352315
- Cited by
- 136
- References
- 73
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis Viruses Studies and Epidemiology
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
- Keywords
- hepatitis A, immunoglobulin prophylaxis, hepatitis A virus, inactivated vaccine, live attenuated vaccine, vaccine immunogenicity, antibody response, post-exposure prophylaxis
- MeSH terms
- Hepatitis A, Humans, Immunization, Passive
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