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Antibody-Dependent Enhancement of Infection and the Pathogenesis of Viral Disease
Abstract
Antibody-dependent enhancement of infection (ADE) is an in vitro serological phenomenon--or a group of phenomena--in which viral infection of susceptible cells is modified by the addition of virus-reactive antibody. Evidence suggests that ADE reflects immunologic processes that occur in vivo. Various severe and even fatal viral conditions of humans and animals, including dengue shock syndrome, the "early-death phenomenon" in experimental infections of immune animals, and other vaccine- and immunoglobulin-modified conditions, have been attributed to ADE by some researchers. ADE has caused great concern in relation to the development of vaccines against dengue virus and human immunodeficiency virus. More data are urgently needed on the mechanisms and determinants of ADE and on its alleged role in disease pathogenesis and in vaccine-associated phenomena.
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Cited by
The challenge of emerging and re-emerging infectious diseases
Morens, D. M., Folkers, G. K., & Fauci, A. S. (2004) · Nature · doi:10.1038/nature02759 · Cited by 2,103
Self-citationGuzmán, M. G., & Kouri, G. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(01)00171-2 · Cited by 1,163
Dengue and dengue haemorrhagic fever
Rigau-Pérez, J. G., Clark, G. G., Gubler, D. J., Reiter, P., Sanders, E. J., & Vance Vorndam, A. (1998) · The Lancet · doi:10.1016/s0140-6736(97)12483-7 · Cited by 1,051
Modified mRNA vaccines protect against zika virus infection
Richner, J. M., Himansu, S., Dowd, K. A., Butler, S. L., Salazar, V., Fox, J. M., Julander, J. G., Tang, W. W., Shresta, S., Pierson, T. C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.02.017 · Cited by 909
The 1918 Influenza Pandemic: Insights for the 21st Century
Morens, D. M., & Fauci, A. S. (2007) · The Journal of Infectious Diseases · doi:10.1086/511989 · Cited by 536
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Metadata
- Authors
- Morens, D. M.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-09-01
- Volume
- 19
- Issue
- 3
- Pages
- 500-512
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2049280865
- Cited by
- 317
- References
- 0
- FWCI
- 11.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Morens, D. M. (1994). Antibody-Dependent Enhancement of Infection and the Pathogenesis of Viral Disease. Clinical Infectious Diseases. https://doi.org/10.1093/clinids/19.3.500
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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