The DOI matches its Crossref record.
Penetration of Antibiotics into Respiratory Secretions
Abstract
Successful treatment of intrabronchial infection depends upon adequate transport of antibiotics across the blood-bronchus barrier. This paper discusses the various influences on antibiotic concentrations in the lung and describes a canine model for detailed pharmacologic studies of antibiotics in bronchial secretion. A number of factors influence antibiotic penetration into bronchial secretions, including physicochemical characteristics of the drug and such host factors as bronchial inflammation and injury. The method of antibiotic administration also influences bronchial drug levels; the highest local concentrations are associated with the highest peak values in serum. In addition, each antibiotic has a characteristic pattern of penetration into bronchial secretions. Optimal methods of antibiotic therapy for lung infection may depend on the specific minimal inhibitory concentration for the infecting organism.
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Citations
Cited by
Practice Guidelines for the Management of Community-Acquired Pneumonia in Adults
Bartlett, J. G., Dowell, S. F., Mandell, L. A., File, T. M., Musher, D. M., & Fine, M. J. (2000) · Clinical Infectious Diseases · doi:10.1086/313954 · Cited by 2,286
Community‐Acquired Pneumonia in Adults: Guidelines for Management
Bartlett, J. G., Breiman, R. F., Mandell, L. A., & File, Jr. (1998) · Clinical Infectious Diseases · doi:10.1086/513953 · Cited by 865
Antibiotic therapy against Pseudomonas aeruginosa in cystic fibrosis: a European consensus
Döring, G., Conway, S. P., Heijerman, H. G. M., Hodson, M. E., Høiby, N., Smyth, A., Touw, D. J., & the Consensus Committee, F. (2000) · European Respiratory Journal · doi:10.1034/j.1399-3003.2000.16d30.x · Cited by 620
Inhibition of Daptomycin by Pulmonary Surfactant: In Vitro Modeling and Clinical Impact
Silverman, J. A., Mortin, L. I., VanPraagh, A. D. G., Li, T., & Alder, J. (2005) · The Journal of Infectious Diseases · doi:10.1086/430352 · Cited by 541
Leggett, J. E., Fantin, B., Ebert, S., Totsuka, K., Vogelman, B., Calame, W., Mattie, H., & Craig, W. A. (1989) · Journal of Infectious Diseases · doi:10.1093/infdis/159.2.281 · Cited by 354
Metadata
- Authors
- Pennington, J. E.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1981-01-01
- Volume
- 3
- Issue
- 1
- Pages
- 67-73
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2154281938
- Cited by
- 192
- References
- 0
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pennington, J. E. (1981). Penetration of Antibiotics into Respiratory Secretions. Clinical Infectious Diseases. https://doi.org/10.1093/clinids/3.1.67
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
