Cited by 1,163COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 ResearchRenin-Angiotensin System Studies

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The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2

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Chen, Liang, Li, Xiangjie, Chen, Mingquan, Feng, Yi, Xiong, Chenglong·2020·Cardiovascular Research

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Abstract

A new type of pneumonia caused by a novel coronavirus SARS-CoV-2 outbreaks recently in China and spreads into many other countries. This disease, named as COVID-19, is similar to patients infected by SARS-CoV and MERS-CoV, and nearly 20% of patients developed severe condition. Cardiac injury is a prevalent complication of severe patients, exacerbating the disease severity in coronavirus disease 2019 (COVID-19) patients. Angiotensin-converting enzyme 2 (ACE2), the key host cellular receptor of SARS-CoV-2, has been identified in multiple organs, but its cellular distribution in human heart is not illuminated clearly. This study performed the first state-of-art single cell atlas of adult human heart, and revealed that pericytes with high expression of ACE2 might act as the target cardiac cell of SARS-CoV-2. The pericytes injury due to virus infection may result in capillary endothelial cells dysfunction, inducing microvascular dysfunction. And patients with basic heart failure disease showed increased ACE2 expression at both mRNA and protein levels, meaning that if infected by the virus these patients may have higher risk of heart attack and critically ill condition. The finding of this study explains the high rate of severe cases among COVID-19 patients with basic cardiovascular disease; and these results also perhaps provide important reference to clinical treatment of cardiac injury among severe patients infected by SARS-CoV-2.

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Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2012-7 · Cited by 21,969 · cited 5×
“Clinical characteristics of coronavirus disease 2019 in China.”
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Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study
Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., Wu, Y., Zhang, L., Yu, Z., Fang, M., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30079-5 · Cited by 10,066 · cited 1×
“Cardiac injury was observed among 23% of severe patients.(3) Even in the general COVID-19 patient cohort, the creatinine kinase (CK) elevation (>200 U/L) was observed in 13%”
Background
Detection of SARS-CoV-2 in Different Types of Clinical Specimens
Wang, W., Xu, Y., Gao, R., Lu, R., Han, K., Wu, G., & Tan, W. (2020) · JAMA · doi:10.1001/jama.2020.3786 · Cited by 5,116 · cited 1×
“Digestive tract intestine displayed the highest expression of ACE2, followed by testis and kidney, suggesting the vulnerability to virus in these organs, which could explain the positive detection of SARS-CoV-2 in patients’ faeces and urine.(6) The expression of ACE2 in the heart is lower than that in the intestine an…”
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The Angiopoietin ligands and Tie receptors: potential diagnostic biomarkers of vascular disease
Bilimoria, J., & Singh, H. (2019) · Journal of Receptors and Signal Transduction · doi:10.1080/10799893.2019.1652650 · Cited by 37 · cited 1×
“As the molecular balance between ANGPT1:ANGPT2 and TIE2:TIE1 is important in determining endothelial stability, 7 it is suggested that pericytes play an important role in maintaining EC function in capillary vessels.”
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“(Chen et al., 2020).”
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Gonçálves, J. M. F., & Golpe, R. (2020) · Medicina Clínica · doi:10.1016/j.medcli.2020.04.015 · Cited by 2
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Hussain, T., Joyce, J., Habib, S., Tousif, S., Ratnani, S., & Puvvada, S. (2021) · Cureus · doi:10.7759/cureus.20348 · Cited by 2
Hyperferritinemia: the link between COVID-19, inflammation, and patient comorbidities
Lazăr, A. M. (2021) · Journal of Ideas in Health · doi:10.47108/jidhealth.vol4.iss4.193 · Cited by 2
“As ACE2 are the receptors for the SARS-CoV-2 [59], a temporary hypothesis was a higher expression of ACE2 receptors in such diseases, male patients, and older age, increasing the risk and severity of SARS-CoV-2 infection [53, 60-65].”
Background
Pathogenesis of CoViD19—Miscellaneous Mechanisms
Mallick, U. (2022) · Springer eBooks · doi:10.1007/978-3-030-90065-6_10 · Cited by 2
Coinfección chagas e infección por covid 19 en una paciente indígena
León, J. S. T., delgado, M. C., Garcia, G. N. P., Meriño, Y. M., Badillo, L. Y. E., Caballero, H. V., & Brilla, M. F. G. (2022) · Ciencia Latina Revista Científica Multidisciplinar · doi:10.37811/cl_rcm.v6i2.2163 · Cited by 2
Cardiovascular Vulnerability to COVID-19 in Cancer SurvivorsPreprint
Zordoky, B. N. M. (2020) · Preprints.org · doi:10.20944/preprints202004.0128.v1 · Cited by 2
“First, Angiotensin Converting Enzyme-2 (ACE2), a key enzyme in the Renin Angiotensin Aldosterone System, has been recognized as a receptor to SARS-CoV-2 [7,8].”
BackgroundInfluential
Lack of Benefit in COVID-19 Patients Treated with Hydroxychloroquine or Chloroquine: A Systematic Review and Meta-AnalysisPreprint
Chen, L., An, S., Yao, G., Xiong, J., Xiong, H., Zhao, P., Jiang, L., Hua, W., Xiong, C., Duru, F., et al. (2020) · doi:10.21203/rs.3.rs-33047/v1 · Cited by 2
Self-citation
Perioperative Cardiac Research Considerations During the Coronavirus Disease 2019 (COVID-19) Pandemic
Clifford, S. P., Ramírez, J. A., Akça, O., Ghafghazi, S., & Huang, J. (2021) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2021.01.052 · Cited by 2
COVID-19: extraño nuevo virus, endotelio y enseñanzas de una pandemia
Enrique Melgarejo, R. (2020) · Acta Médica Colombiana · doi:10.36104/amc.2020.1918 · Cited by 2
Endocrinology, Diabetes and Obesity
(2018) · Endocrinology Diabetes and Obesity · doi:10.31532/endocrinoldiabetesobes · Cited by 2
“Heart failure in COVID-19 patients: Critical care experience”: A letter to the editor
Tsigkou, V., Siasos, G., Oikonomou, E. K., Bletsa, E., Vavuranakis, Μ., & Tousoulis, D. (2022) · World Journal of Virology · doi:10.5501/wjv.v11.i4.216 · Cited by 2
The Long Covid-19 Syndrome the Spike Protein and Stem Cells, the Underrated Role of Retrotransposons, a Working HypothesisPreprint
Balzanelli, M. G., Distratis, P., Lazzaro, R., Dipalma, G., Inchingolo, F., Prete, R. D., Pham, V. H., Aityan, S. K., Nguyen, K. C. D., & Isacco, C. G. (2023) · Preprints.org · doi:10.20944/preprints202308.1130.v1 · Cited by 1
["Prioritization and triage" in the context of cardiovascular diseases : Rational organization of safe care during and outside the corona pandemic].
Velichkov, M., Schulze, P. C., & Otto, S. (2021) · PubMed Central · doi:10.1007/s00108-021-01079-w · Cited by 1
“Das ACE2 wird bei kardialen Erkrankungen hochreguliert, was die Anfälligkeit und Reaktion auf eine SARS-CoV2-Infektion in kardiovaskulär Erkrankten impliziert [25].”
Background
Transcriptomics Curation of SARS-CoV-2 Related Host Genes in Mice With COVID-19 Comorbidity: A Pilot Study
Su, K., Huang, X., Xu, K., Du, W., Zhu, D., Yang, M., Yuan, W., & Li, L. (2020) · Infectious Microbes & Diseases · doi:10.1097/im9.0000000000000025 · Cited by 1
INNOVATIVE APPROACHES IN MEDICINE
International Science Group, & Vladlenov, D. (2020) · Іnternational Science Group eBooks · doi:10.46299/isg.2020.mono.med.iii · Cited by 1
COVID-19 Pandemisinde Acil Servise Başvuran Hastaların Kan Parametrelerinin Hastalığı Öngörmedeki Başarısının Değerlendirilmesi
Güneysu, F., Durmuş, E., & Yürümez, Y. (2021) · Sakarya Medical Journal · doi:10.31832/smj.930242 · Cited by 1
Severe Acute Respiratory Syndrome Coronavirus Associated Myocarditis
Wantania, F. E. N., Wowor, R. E., & Tandiawan, R. (2021) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2021.6498 · Cited by 1
“Genetic predisposition appears to also play a role to some extent in inducing arrhythmia in SARS-CoV-2 infection [5], [13] (Figure 2).”
Background
Cardiovascular therapy use, modification, and in-hospital death in patients with COVID-19: A cohort study
Follonier, C., Tessitore, E., Handgraaf, S., Carballo, D., Achard, M., Péchère-Bertschi, A., Mach, F., Herrmann, F. R., & Girardin, F. R. (2022) · PLoS ONE · doi:10.1371/journal.pone.0277653 · Cited by 1
The COVID-19 Pandemic in South Asia: A Comprehensive Review of the Genomic Variations, Epidemiological Features, Diagnosis, Treatment and Preventive Schemes
Noman, A. A., Ekra, J. E., Meem, R. I., Islam, S., Sharzana, F., Islam, S., Sana, S., Mahmud, N., Kabir, M., Mahedi, A. A., et al. (2022) · Journal of Health Research · doi:10.56808/2586-940x.1018 · Cited by 1
Evaluation of some laboratory parameters and their diagnostic and prognostic role in COVID-19 patients admitted to Syrian hospitals
Akkari, M. T., Al-Kayali, R., & Ibrahim, A. (2023) · Zagazig Journal of Pharmaceutical Sciences/Zagazig Journal of Pharmaceutical Science · doi:10.21608/zjps.2023.221071.1051 · Cited by 1
Role of Serum NT-proBNP Levels in Early Prediction of Prognosis in Severe COVID-19 Pneumonia
Atmaca, H. U., Çiçek, N. E., & Pişkinpaşa, M. E. (2023) · Istanbul Medical Journal · doi:10.4274/imj.galenos.2023.90094 · Cited by 1
An In-Depth Insight into Clinical, Cellular and Molecular Factors in COVID19-Associated Cardiovascular Ailments for Identifying Novel Disease Biomarkers, Drug Targets and Clinical Management Strategies
AlTaweel, M., Almusaad, A., Alkhazmari, G., Alrowaily, H., AlSubaiee, M., Husain, M. A., Alomayrin, N., Muaiweed, R. A., Aleid, N., Alarfaj, A. A., et al. (2024) · Archives of Microbiology & Immunology · doi:10.26502/ami.936500177 · Cited by 1
The Role of ACE2 Receptor and Its Polymorphisms in COVID-19 Infection and Severity and Its Association with Lipid Profile, Thrombin, and D-Dimer Levels in Iraqi Patients: A Cross-Sectional Study
Hatem, B. A., & Jabir, F. A. (2024) · Biochemical Genetics · doi:10.1007/s10528-024-10890-7 · Cited by 1
“Chen et al. (2020) investigated the association between ACE2 gene polymorphisms and COVID-19 severity in a Chinese population.”
Post‐acute sequelae of COVID ‐19 in cancer patients: Two cohorts in UK and Hong Kong
Wan, E. Y. F., Lee, S. F., Zhou, J., Yan, V. K. C., Lai, F. T. T., Chui, C. S. L., Li, X., Wong, C. K. H., Chan, E. W., & Wong, I. C. K. (2024) · Cancer Medicine · doi:10.1002/cam4.70134 · Cited by 1
Self-citation
Fatores associados à mortalidade de pacientes com doenças cardiovasculares acometidos pela COVID-19: estudo transversal
Carvalho, M. C., Fernandes, F. E. C. V., Almeida, M. V. D. S., dos Santos, J. M. A., Amestoy, S. C., & de Melo, R. A. (2025) · Revista Latino-Americana de Enfermagem · doi:10.1590/1518-8345.7609.4552 · Cited by 1
COVID-19 as Potential Cause of Aortic Valvulitis
Warren, B., Patel, A., Pasupuleti, S., & Kotwani, R. (2025) · Methodist DeBakey Cardiovascular Journal · doi:10.14797/mdcvj.1499 · Cited by 1
“7 Therefore, virus-infected pericytes can lead to capillary endothelial cell dysfunction and, ultimately, impairment in the microcirculation of the cardiovascular tissue.”
SARS-CoV-2 infection of 3D in vitro cardiac spheroids models the activation of antiviral, inflammatory, fibrotic, and contractile responses in a dose-dependent manner
Johansen, M. D., Ming, C. L. C., Hansbro, P. M., & Gentile, C. (2026) · Biofabrication · doi:10.1088/1758-5090/ae38d7 · Cited by 1
“These findings agree with earlier studies, which have shown that OAS family genes are significantly elevated in SARS-CoV-2-infected cardiomyocytes and COVID-19 heart failure (Gao et al , 2023).”
Influential
Potential predictors of COVID-19 disease infection and severity in Egypt
Abdelraheem, W. M., Shady, R. R., Mahdi, W. K. M., Bassyouni, M., Kamel, H. S., Mousa, Y. M., Kamel, S. F., Saber, M. M., & Abdelrahim, S. S. (2026) · Scientific Reports · doi:10.1038/s41598-025-34444-y · Cited by 1
Myocardial and Vascular Involvement in COVID-19 and Post-Vaccination States: Understanding Injury Pathways and Clinical Implications
Siliste, R., Benea, S. N., Homentcovschi, C., Deaconu, T., Căruntu, C., & Săvulescu-Fiedler, I. (2026) · Life · doi:10.3390/life16020268 · Cited by 1
“In any case, ACE2 levels in the heart are lower than in the intestine and kidney, but higher than in the lung [6].”
Influential
Five-year cardiovascular outcomes following COVID-19-associated carditis
Hadidchi, R., Ali, E., Shih, W. K., Zhao, W., Ragupathi, S., Bisulca, J., Le, T. T. B., Henry, S. S., & Duong, T. Q. (2026) · Clinical Research in Cardiology · doi:10.1007/s00392-026-02863-0 · Cited by 1
Heart Rate Recovery After Six-Minute Walk Test, Pulmonary Function, Dyspnea, and Functional Status After COVID-19
Fonseca, A. L., Oliveira, M. C., Fonseca, D. R. P., Afonso, J. P. R., Paixão, H. N. C., Júnior, J. B. S. R., Alves, L. R., Fernandes, T. V., Marconi, D. G., Andraus, R. A. C., et al. (2026) · COVID · doi:10.3390/covid6050082 · Cited by 1
Human Stem Cell Models of SARS-CoV-2 Infection in the Cardiovascular System
Ernzen, K., Trask, A. J., Peeples, M. E., Garg, V., & Zhao, M. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10229-4 · Cited by 1
Long Covid: A Review on Cardiovascular Disease (CVD) in Post-Acute Sequalae of SARS-CoV-2 Infection (PASC)
(2021) · Biointerface Research in Applied Chemistry · doi:10.33263/briac123.39893995 · Cited by 1
SARS-Cov-2 and Associated Heart Failure
Aimrane, A., El‐Mansoury, B., Sabir, E., Baz, S. E., Zouhairi, N., Echchakery, M., Draoui, A., Chatoui, H., Fdil, N., Sellami, S., et al. (2021) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-7998-8225-1.ch010 · Cited by 1
SINDROM COVID-19 YANG MEMANJANG DAN KAITANNYA DENGAN KARDIOVASKULAR: SUDUT PANDANG KARDIOLOG
Laksono, S. (2022) · Medika Kartika Jurnal Kedokteran dan Kesehatan · doi:10.35990/mk.v5n1.p103-111 · Cited by 1
Cerebral venous sinus thrombosis in COVID 19 patients: Report of 2 cases
Taha, M. M., Taha, M. M., Menshawy, H. A. A., & Elsharkawy, A. M. (2022) · Interdisciplinary Neurosurgery · doi:10.1016/j.inat.2022.101599 · Cited by 1
Managing Covid-19 in patients with heart failure: current status and future prospects
Prameswari, H. S., Putra, I. C. S., Raffaello, W. M., Nathaniel, M., Suhendro, A. S., Khalid, A. F., & Pranata, R. (2022) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2022.2132230 · Cited by 1
Mechanisms of atrial fibrillation in COVID-19
Moseichuk, K. A., & Филиппов, Е. В. (2023) · Journal of Arrhythmology · doi:10.35336/va-2023-1-11 · Cited by 1
Associations of polymorphisms of the ACE and ACE2 genes with clinical manifestations and cardiovascular complications of the coronavirus infection
Bogdanov, D. S., Cherkashin, D. V., Ефимов, С. В., & Zakharova, A. I. (2023) · Bulletin of the Russian Military Medical Academy · doi:10.17816/brmma114802 · Cited by 2
A critical review on brain and heart axis response in COVID‐19 patients: Molecular mechanisms, mediators, biomarkers, and therapeutics
Mishra, K. A., Podili, R., Pathlavath, T. S., & Sethi, K. K. (2023) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23409 · Cited by 1
Tissue expression of the SARS-CoV-2 cell receptor gene ACE2 in children
Huang, J., Guo, Z., Duan, J., Zou, Y., Chen, K., Huang, H., Zhang, S., & Zhou, Y. (2023) · Journal of Tropical Pediatrics · doi:10.1093/tropej/fmad027 · Cited by 1
Clinical and Morphological Features of Myocardial Infarction in Patients With a New Coronavirus Infection COVID-19
Zavyalova, M. V., Neklyudov, A. A., Васильевич, З. А., Сергеевна, А. Е., Михайлович, П. Ю., Вячеславовна, Б. М., Krakhmal, N. V., & Vtorushin, S. V. (2023) · Kardiologiia · doi:10.18087/cardio.2023.8.n2139 · Cited by 1

Authors: Chen, L., Li, X., Chen, M., Feng, Y., & Xiong, C.
Affiliations: Fudan University (CN)
Renmin University of China (CN)
Corresponding author: Chen, Liang
Xiong, Chenglong
ORCID: Chen, Liang
Li, Xiangjie
Chen, Mingquan
Feng, Yi
Xiong, Chenglong
Venue: Cardiovascular Research
Publisher: Oxford University Press (OUP)
Published: 2020-03-30
Volume: 116
Issue: 6
Pages: 1097-1100
ISSN: 0008-6363 (ISSN-L)
1755-3245
DOI: 10.1093/cvr/cvaa078
PMC: PMC7184507
OpenAlex: W3014027512
Cited by: 1,163
References: 7
Citations by year: 2026: 19 · 2025: 32 · 2024: 64 · 2023: 148 · 2022: 210 · 2021: 332 · 2020: 355
FWCI: 34.28
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Cardiovascular Research (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (81872673)
National Key Research and Development Program of China (2017YFC1200203)
Fudan University
Topics: Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Keywords: ACE2, SARS-CoV-2, COVID-19 pandemic, cardiac injury, pericytes, microvascular dysfunction, heart failure, viral receptor expression, myocardial injury
MeSH terms: Betacoronavirus, Receptors, Coronavirus, Angiotensin-Converting Enzyme 2, COVID-19, SARS-CoV-2, Heart, Heart Diseases, Humans, Peptidyl-Dipeptidase A, Myocardium, Pneumonia, Viral, Receptors, Virus, Gene Expression, Coronavirus Infections, Pericytes, Gene Expression Profiling, Pandemics, Spike Glycoprotein, Coronavirus

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The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2

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