Telomere biology in cardiovascular disease: the TERC-/- mouse as a model for heart failure and ageing
Abstract
Atherosclerosis and heart failure are major causes of morbidity and mortality in Western countries. Recent studies are suggesting involvement of telomere biology in the development and progression of age-associated conditions, including hypertension, atherosclerosis, and heart failure. Whether any of these reported associations are based on causal relationships remains to be elucidated. The construction of telomerase-deficient (telomerase RNA component, TERC(-/-)) mice might provide a potential instrumental model to study the involvement of telomere biology in cardiovascular disease. Here, we review the current available information from all studies performed in TERC(-/-) mice providing information on the cardiovascular phenotypic characteristics. Although this mouse model has proven its value in the understanding of the role of telomere biology in cancer, stem cell, and basic telomere research, only few studies were specifically designed to answer cardiovascular-related questions. The TERC(-/-) mice provide exciting opportunities to expand our knowledge of telomere biology in cardiovascular disease and the potential identification of novel targets of treatment.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Short and dysfunctional telomeres have a causal role in cardiac diseases in mice.
“A causal role of short and dysfunctional telomeres in cardiac diseases has been established in mice110.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [110]
Section 4.6 (page unavailable) reports that late-generation TERC-deficient mice with shortened telomeres develop severe ventricular failure, supporting a role in mouse cardiac disease. But the paper describes these findings as suggestive, while Section 3.3 says definite proof of a causal role in heart failure has not been generated. The claim overstates the certainty of the evidence. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 78 · Cited by 88
- Authors
- Wong, L. S. M., Oeseburg, H., de Boer, R. A., van Gilst, W. H., van Veldhuisen, D. J., & van der Harst, P.
- Affiliations
- University Medical Center Groningen (NL)
- Corresponding author
- Wong, L. S.M.
- Oeseburg, H.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-12-01
- Volume
- 81
- Issue
- 2
- Pages
- 244-252
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2167247475
- Cited by
- 88
- References
- 78
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 10 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 8 · 2014: 4 · 2013: 6 · 2012: 4
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiovascular Research (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (916.76.170)
- Netherlands Heart Institute
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- telomere biology, telomerase RNA, heart failure, aging, atherosclerosis, hypertension, cardiovascular disease, mouse model
- MeSH terms
- Aging, Animals, Cardiovascular Diseases, Disease Models, Animal, Heart Failure, Hypertension, Regeneration, Stem Cells, Signal Transduction, Telomere, Telomerase, Atherosclerosis, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
