The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Matrix ageing and vascular impacts: focus on elastin fragmentation
Abstract
Cardiovascular diseases (CVDs) are the leading cause of death worldwide and represent a major problem of public health. Over the years, life expectancy has considerably increased throughout the world, and the prevalence of CVD is inevitably rising with the growing ageing of the population. The normal process of ageing is associated with progressive deterioration in structure and function of the vasculature, commonly called vascular ageing. At the vascular level, extracellular matrix (ECM) ageing leads to molecular alterations in long half-life proteins, such as elastin and collagen, and have critical effects on vascular diseases. This review highlights ECM alterations occurring during vascular ageing with a specific focus on elastin fragmentation and also the contribution of elastin-derived peptides (EDP) in age-related vascular complications. Moreover, current and new pharmacological strategies aiming at minimizing elastin degradation, EDP generation, and associated biological effects are discussed. These strategies may be of major relevance for preventing and/or delaying vascular ageing and its complications.
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Diabetes and obesity: the twin epidemics
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Hinek, A., Pshezhetsky, A. V., von Itzstein, M., & Starcher, B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508736200 · Cited by 176
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Cited by
Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease
Lacolley, P., Regnault, V., Segers, P., & Laurent, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00003.2017 · Cited by 734
The role of infiltrating immune cells in dysfunctional adipose tissue
Guzik, T. J., Skiba, D. S., Touyz, R. M., & Harrison, D. G. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx108 · Cited by 445
Elastin, arterial mechanics, and cardiovascular disease
Cocciolone, A. J., Hawes, J. Z., Staiculescu, M. C., Johnson, E. O., Murshed, M., & Wagenseil, J. E. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00087.2018 · Cited by 341
Ke, Y., Li, D., Zhao, M., Liu, C., Liu, J., Zeng, A., Shi, X., Cheng, S., Pan, B., Zheng, L., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.01.007 · Cited by 285
Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging
Fedintsev, A., & Moskalev, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101097 · Cited by 72
Metadata
- Authors
- Duca, L., Blaise, S., Romier, B., Laffargue, M., Gayral, S., El Btaouri, H., Kawecki, C., Guillot, A., Martiny, L., Debelle, L., & Maurice, P.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-03-22
- Volume
- 110
- Issue
- 3
- Pages
- 298-308
- ISSN
- 0008-6363 (ISSN-L)
- 1755-3245
- OpenAlex
- W2304685302
- Cited by
- 260
- References
- 4
- FWCI
- 13.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Duca, L., Blaise, S., Romier, B., Laffargue, M., Gayral, S., El Btaouri, H., Kawecki, C., Guillot, A., Martiny, L., Debelle, L., & Maurice, P. (2016). Matrix ageing and vascular impacts: focus on elastin fragmentation. Cardiovascular Research. https://doi.org/10.1093/cvr/cvw061
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
