The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
A decade of genome-wide association studies for coronary artery disease: the challenges ahead
Open accessAbstract
In this review, we summarize current knowledge on the genetics of coronary artery disease, based on 10 years of genome-wide association studies. The discoveries began with individual studies using 200K single nucleotide polymorphism arrays and progressed to large-scale collaborative efforts, involving more than a 100 000 people and up to 40 Mio genetic variants. We discuss the challenges ahead, including those involved in identifying causal genes and deciphering the links between risk variants and disease pathology. We also describe novel insights into disease biology based on the findings of genome-wide association studies. Moreover, we discuss the potential for discovery of novel treatment targets through the integration of different layers of 'omics' data and the application of systems genetics approaches. Finally, we provide a brief outlook on the potential for precision medicine to be enhanced by genome-wide association study findings in the cardiovascular field.
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Cites
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Metadata
- Authors
- Erdmann, J., Kessler, T., Munoz Venegas, L., & Schunkert, H.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-03-30
- Volume
- 114
- Issue
- 9
- Pages
- 1241-1257
- ISSN
- 0008-6363 (ISSN-L)
- 1755-3245
- OpenAlex
- W2795181515
- Cited by
- 325
- References
- 120
- FWCI
- 19.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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