CoChat
Sign Up
Cited by 62Congenital Heart Disease StudiesCardiovascular Function and Risk FactorsCardiac Valve Diseases and Treatments

Assessment of ventricular function in adults with repaired Tetralogy of Fallot using myocardial deformation imaging

Menting, Myrthe E., van den Bosch, Annemien E., McGhie, Jackie S., Eindhoven, Jannet A., Cuypers, Judith A.A.E., Witsenburg, Maarten, Geleijnse, Marcel L., Helbing, Willem A. +1 more·2015·European Heart Journal – Cardiovascular Imaging
DOI 10.1093/ehjci/jev090
Open this paper in CoChat — free account

Abstract

Aims Many patients with repaired Tetralogy of Fallot (ToF) have right ventricular (RV) volume overload due to pulmonary regurgitation (PR). We studied the effect of volume overload on global and regional RV and left ventricular (LV) deformation, and their relationships with conventional diagnostic parameters. Methods and results In this cross-sectional study, 94 prospectively recruited ToF patients (61% male, age 32.8 ± 9.5 years, age at repair 1.9 [0.8-5.7] years, 39% pulmonary homograft) and 85 healthy controls of similar age and sex underwent echocardiography and electrocardiography. In a subset of patients, cardiac magnetic resonance imaging, bicycle ergometry, and NT-proBNP measurement were performed within the same day. With speckle-tracking echocardiography, we analysed peak systolic global longitudinal strain (GLS), segmental longitudinal strain and strain rate of the RV free wall, LV lateral wall, and septum. Patients had a lower RV free wall strain than controls (-18.1 ± 4.5 vs. -26.5 ± 4.5%, P 25% had higher LV GLS and RV free wall strain than patients with PR ≤25% (P = 0.004, P = 0.039, respectively). No relationships were found with NT-proBNP or exercise capacity. Conclusion RV free wall strain and strain rate are decreased in adults late after ToF repair, especially at the apical segment suggesting that apical function is most affected in these RVs. Regarding the LV, septal strain is decreased indicating that RV dysfunction adversely affects LV function, probabl…

Integrity signals

Registry

Crossref · 10.1093/ehjci/jev090

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Recent studies have found relevant correlations between impaired clinical status and reduced left ventricular systolic deformation, as measured by speckle-tracking analysis, in patients with repaired TOF.

    “Recent studies have discovered relevant correlations between impaired clinical status and reduced left ventricular (LV) systolic deformation, as measured by speckle-tracking analysis, in patients with repaired TOF [19].”

    From Multimodality imaging assessment of tetralogy of Fallot: From diagnosis to long-term follow-up (2023) · cites this paper as [19]

Cited by

Sorted by citations

Authors
Menting, M. E., van den Bosch, A. E., McGhie, J. S., Eindhoven, J. A., Cuypers, J. A. A. E., Witsenburg, M., Geleijnse, M. L., Helbing, W. A., & Roos-Hesselink, J. W.
Affiliations
Erasmus MC (NL)
ORCID
Venue
European Heart Journal – Cardiovascular Imaging
Publisher
Oxford University Press (OUP)
Published
2015-07-29
Volume
16
Issue
12
Pages
jev090
ISSN
  • 2047-2404 (ISSN-L)
  • 2047-2412
DOI
10.1093/ehjci/jev090
OpenAlex
W2161973313
Cited by
62
References
0
Citations by year
2025: 3 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 10 · 2019: 7 · 2018: 8 · 2017: 11 · 2016: 3
FWCI
5.75
Type
journal article
Language
en
Open access
closed
Locations
  • European Heart Journal - Cardiovascular Imaging (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Funders
Erasmus MC Thorax Foundation
Topics
  • Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
Keywords
repaired tetralogy of Fallot, right ventricular volume overload, pulmonary regurgitation, myocardial deformation, global longitudinal strain, strain rate, right ventricular dysfunction, left ventricular function, interventricular septum, speckle tracking echocardiography
MeSH terms
Adult, Cross-Sectional Studies, Echocardiography, Electrocardiography, Exercise Test, Female, Humans, Magnetic Resonance Imaging, Male, Peptide Fragments, Prospective Studies, Tetralogy of Fallot, Biomarkers, Ventricular Dysfunction, Left, Ventricular Dysfunction, Right, Natriuretic Peptide, Brain

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review