The DOI matches its Crossref record; 290 of the 290 references it cites were found in a registry or an index.
Gender differences in the effects of cardiovascular drugs
Open accessAbstract
Although sex-specific differences in cardiovascular medicine are well known, the exact influences of sex on the effect of cardiovascular drugs remain unclear. Women and men differ in body composition and physiology (hormonal influences during the menstrual cycle, menopause, and pregnancy) and they present differences in drug pharmacokinetics (absorption, distribution, metabolism, and excretion) and pharmacodynamics, so that is not rare that they may respond differently to cardiovascular drugs. Furthermore, women are also less often treated with evidence-based drugs thereby preventing optimization of therapeutics for women of all ages, experience more relevant adverse drug reactions than men, and remain underrepresented in most clinical trials. Thus, current guidelines for prevention, diagnosis, and medical treatment for cardiovascular diseases are based on trials conducted predominantly in middle-aged men. A better understanding of these sex-related differences is fundamental to improve the safety and efficacy of cardiovascular drugs and for developing proper individualized cardiovascular therapeutic strategies both in men and women. This review briefly summarizes gender differences in the pharmacokinetics and pharmacodynamics of cardiovascular drugs and provides recommendations to close the gaps in our understanding of sex-specific differences in drug efficacy and safety.
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Cites
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Cited by
Sex differences in pharmacokinetics predict adverse drug reactions in women
Zucker, I., & Prendergast, B. J. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00308-5 · Cited by 777
Gender medicine: effects of sex and gender on cardiovascular disease manifestation and outcomes
Regitz-Zagrosek, V., & Gebhard, C. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00797-4 · Cited by 386
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Impact of gastrointestinal physiology on drug absorption in special populations––An UNGAP review
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Metadata
- Authors
- Tamargo, J., Rosano, G., Walther, T., Duarte, J., Niessner, A., Kaski, J., Ceconi, C., Drexel, H., Kjeldsen, K., Savarese, G., Torp-Pedersen, C., Atar, D., Lewis, B., & Agewall, S.
- Venue
- European Heart Journal - Cardiovascular Pharmacotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-02-28
- Volume
- 3
- Issue
- 3
- Pages
- 163-182
- ISSN
- 2055-6837 (ISSN-L)
- 2055-6845
- OpenAlex
- W2592398938
- Cited by
- 317
- References
- 290
- FWCI
- 13.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tamargo, J., Rosano, G., Walther, T., Duarte, J., Niessner, A., Kaski, J., Ceconi, C., Drexel, H., Kjeldsen, K., Savarese, G., Torp-Pedersen, C., Atar, D., Lewis, B., & Agewall, S. (2017). Gender differences in the effects of cardiovascular drugs. European Heart Journal - Cardiovascular Pharmacotherapy. https://doi.org/10.1093/ehjcvp/pvw042
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
