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Cited by 114Cardiac, Anesthesia and Surgical OutcomesCardiac and Coronary Surgery TechniquesLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 74 of the 76 references it cites were found in a registry or an index.

Preoperative statin therapy in cardiac surgery: a meta-analysis of 90,000 patients

Kuhn, Elmar W., Liakopoulos, Oliver J., Stange, Sebastian, Deppe, Antje-Christin, Slottosch, Ingo, Choi, Yeong-Hoon, Wahlers, Thorsten·2014·European Journal of Cardio-Thoracic Surgery
DOI 10.1093/ejcts/ezt181
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Abstract

The objective of this systematic literature review with meta-analysis was to determine the strength of evidence for a preoperative statin on the reduction of adverse postoperative outcomes in patients undergoing cardiac surgery. Randomized controlled (RCT) and observational trials were searched in online databases that reported about the effects of preoperative statin therapy on major adverse clinical outcomes after cardiac surgery. Analysed outcomes included early all-cause mortality, myocardial infarction, atrial fibrillation (AF), stroke and renal failure using a priori-defined criteria. Effect estimates were calculated and are given as odds ratio (OR) with 95% confidence intervals (95% CI) using fixed- or random-effect models. Literature search of all major databases retrieved 2371 studies. After screening, a total of 54 trials were identified (12 RCT, 42 observational) that reported outcomes of 91 491 cardiac surgery patients with (n = 46 614; 51%) or without (n = 44 877; 49%) preoperative statin therapy. Preoperative statin use resulted in a 0.9% absolute risk (2.6 vs 3.5%) and a 31% odds reduction for early all-cause mortality (OR 0.69; 95% CI 0.59-0.81; P < 0.0001). In addition, statin treatment before surgery was associated with a substantial reduction (P < 0.01) in the postoperative end-points AF (OR 0.71; 95% CI 0.61-0.82), new-onset AF (OR 0.68; 95% CI 0.54-0.85), stroke (OR 0.83; 95% CI 0.74-0.93), stay on intensive care unit (weighted mean difference [WMD] -0.14; 95% CI -0.23 to -0.03; P < 0.01) and in-hospital stay (WMD -0.57; 95% CI -0.76 to -0.38; P < 0.01). No statistical differences were found between groups with regard to myocardial infarction or renal failure. In conclusion, the current systematic review strengthens the evidence that preoperative statin therapy extends substantial clinical benefit to early postoperative outcomes in cardiac surgery patients.

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Crossref · 10.1093/ejcts/ezt181

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  1. Kuhn, 2010, Statins improve surgical ablation outcomes for atrial fibrillation in patients undergoing concomitant cardiac surgery, Interact CardioVasc Thorac Surg, 11(1), 24, 10.1510/icvts.2009.230060 · DOI

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Metadata

Authors
Kuhn, E. W., Liakopoulos, O. J., Stange, S., Deppe, A.-C., Slottosch, I., Choi, Y.-H., & Wahlers, T.
Affiliations
University of Cologne (DE)
Corresponding author
Liakopoulos, Oliver J.
ORCID
Venue
European Journal of Cardio-Thoracic Surgery
Publisher
Oxford University Press (OUP)
Published
2013-04-05
Volume
45
Issue
1
Pages
17-26
ISSN
  • 1010-7940 (ISSN-L)
  • 1873-734X
DOI
10.1093/ejcts/ezt181
OpenAlex
W2149111184
Cited by
114
References
76
Citations by year
2026: 6 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 9 · 2019: 6 · 2018: 8 · 2017: 14 · 2016: 20 · 2015: 13 · 2014: 10 · 2013: 4
FWCI
2.66
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Cardio-Thoracic Surgery (publishedVersion)
  • PubMed (publishedVersion)
  • Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac, Anesthesia and Surgical Outcomes
  • Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords
preoperative statin therapy, cardiac surgery, all-cause mortality, atrial fibrillation, postoperative stroke, ICU length of stay, length of hospital stay, myocardial infarction, renal failure, statins, hypercholesterolemia, dyslipidemia, hypertriglyceridemia, hyperglycemia
MeSH terms
Coronary Artery Bypass, Atrial Fibrillation, Cardiac Surgical Procedures, Humans, Length of Stay, Myocardial Infarction, Postoperative Complications, Preoperative Care, Treatment Outcome, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Renal Insufficiency

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