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Membrane raft microdomains mediate lateral assemblies required for HIV‐1 infection
Open accessAbstract
HIV‐1 infection triggers lateral membrane diffusion following interaction of the viral envelope with cell surface receptors. We show that these membrane changes are necessary for infection, as initial gp120–CD4 engagement leads to redistribution and clustering of membrane microdomains, enabling subsequent interaction of this complex with HIV‐1 co‐receptors. Disruption of cell membrane rafts by cholesterol depletion before viral exposure inhibits entry by both X4 and R5 strains of HIV‐1, although viral replication in infected cells is unaffected by this treatment. This inhibitory effect is fully reversed by cholesterol replenishment of the cell membrane. These results indicate a general mechanism for HIV‐1 envelope glycoprotein‐mediated fusion by reorganization of membrane microdomains in the target cell, and offer new strategies for preventing HIV‐1 infection.
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Citations
Cited by
Cholesterol, lipid rafts, and disease
Simons, K., & Ehehalt, R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216390 · Cited by 916
Virus Entry, Assembly, Budding, and Membrane Rafts
Chazal, N., & Gerlier, D. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.2.226-237.2003 · Cited by 482
How C-type lectins detect pathogens: C-type lectins and pathogens
Cambi, A., Koopman, M., & Figdor, C. G. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00506.x · Cited by 448
Dietrich, C., Volovyk, Z. N., Levi, M., Thompson, N. L., & Jacobson, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191168698 · Cited by 329
Role for Human Immunodeficiency Virus Type 1 Membrane Cholesterol in Viral Internalization
Guyader, M., Kiyokawa, E., Abrami, L., Turelli, P., & Trono, D. (2002) · Journal of Virology · doi:10.1128/jvi.76.20.10356-10364.2002 · Cited by 170
Metadata
- Authors
- Mañes, S., del Real, G., Lacalle, R. A., Lucas, P., Gómez‐Moutón, C., Sánchez‐Palomino, S., Delgado, R., Alcamí, J., Mira, E., & Martínez‐A, C.
- Venue
- EMBO reports
- Published
- 2000-08
- Volume
- 1
- Issue
- 2
- Pages
- 190-196
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2153052569
- Cited by
- 362
- References
- 0
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mañes, S., del Real, G., Lacalle, R. A., Lucas, P., Gómez‐Moutón, C., Sánchez‐Palomino, S., Delgado, R., Alcamí, J., Mira, E., & Martínez‐A, C. (2000). Membrane raft microdomains mediate lateral assemblies required for HIV‐1 infection. EMBO reports. https://doi.org/10.1093/embo-reports/kvd025
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
