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Cited by 446Ion channel regulation and functionIon Transport and Channel RegulationCancer-related Molecular Pathways

Oncogenic potential of EAG K+ channels

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Pardo, Luis A., del Camino, Donato, Sánchez, Araceli, Alves, Frauke, Brüggemann, Andrea, Beckh, Synnöve, Stühmer, Walter·1999·The EMBO Journal
DOI 10.1093/emboj/18.20.5540PMC PMC1171622
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Abstract

We have investigated the possible implication of the cell cycle-regulated K(+) channel ether à go-go (EAG) in cell proliferation and transformation. We show that transfection of EAG into mammalian cells confers a transformed phenotype. In addition, human EAG mRNA is detected in several somatic cancer cell lines, despite being preferentially expressed in brain among normal tissues. Inhibition of EAG expression in several of these cancer cell lines causes a significant reduction of cell proliferation. Moreover, the expression of EAG favours tumour progression when transfected cells are injected into immune-depressed mice. These data provide evidence for the oncogenic potential of EAG.

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Crossref · 10.1093/emboj/18.20.5540

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  • Inhibition of EAG channel expression reduces proliferation in several cancer cell lines, whereas implantation of CHO cells over-expressing EAG channels in mice induces tumors.

    “Inhibition of EAG channel expression reduces proliferation in several cancer cell lines, whereas implantation of CHO cells over-expressing EAG channels in mice induces tumors (Pardo et al., 1999).”

    From Membrane potential and cancer progression (2013) · cites this paper as Pardo et al., 1999

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Authors
Pardo, L. A., del Camino, D., Sánchez, A., Alves, F., Brüggemann, A., Beckh, S., & Stühmer, W.
Affiliations
  • Max Planck Institute of Experimental Medicine (DE)
  • Universitätsmedizin Göttingen (DE)
Corresponding author
Pardo, Luis A.
ORCID
Venue
The EMBO Journal
Publisher
Springer Science and Business Media LLC
Published
1999-10-15
Volume
18
Issue
20
Pages
5540-5547
ISSN
  • 0261-4189 (ISSN-L)
  • 1460-2075
DOI
10.1093/emboj/18.20.5540
PMC
PMC1171622
OpenAlex
W1970120474
Cited by
446
References
0
Citations by year
2026: 9 · 2025: 6 · 2024: 11 · 2023: 12 · 2022: 13 · 2021: 12 · 2020: 22 · 2019: 13 · 2018: 7 · 2017: 22 · 2016: 27 · 2015: 20 · 2014: 24 · 2013: 24 · 2012: 30
FWCI
2.53
Type
journal article
Language
en
Open access
Licence
Locations
  • The EMBO Journal (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords
ether-a-go-go potassium channel, oncogenicity, cell transformation, cell proliferation, tumor progression, tumor xenografts
MeSH terms
Animals, Base Sequence, Cell Division, Cell Transformation, Neoplastic, Cloning, Molecular, Humans, Molecular Sequence Data, Neoplasms, Experimental, Phenotype, RNA, Messenger, Tumor Cells, Cultured, Potassium Channels, Gene Expression, Mice, SCID, In Situ Hybridization, Fluorescence, DNA Primers, Oligodeoxyribonucleotides, Antisense, Mice, Ether-A-Go-Go Potassium Channels

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