The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579
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Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,221
Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms
Beavo, J. A. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.4.725 · Cited by 1,767
Chijiwa, T., Mishima, A., Hagiwara, M., Sano, M., Hayashi, K., Inoue, T., Naito, K., Toshioka, T., & Hidaka, H. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)34116-x · Cited by 1,484
Inhibition by cAMP of Ras-Dependent Activation of Raf
Cook, S. J., & McCormick, F. (1993) · Science · doi:10.1126/science.7694367 · Cited by 922
Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate
Wu, J., Dent, P., Jelinek, T., Wolfman, A., Weber, M. J., & Sturgill, T. W. (1993) · Science · doi:10.1126/science.7694366 · Cited by 919
Pang, L., Sawada, T., Decker, S. J., & Saltiel, A. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.23.13585 · Cited by 896
A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf
Lange-Carter, C. A., Pleiman, C. M., Gardner, A. M., Blumer, K. J., & Johnson, G. L. (1993) · Science · doi:10.1126/science.8385802 · Cited by 827
Phosphodiesterase Isozymes: Molecular Targets for Novel Antiasthma Agents
TORPHY, T. J. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.2.9708012 · Cited by 657
Cited by
Chen, Z., Gibson, T. B., Robinson, F., Silvestro, L., Pearson, G., Xu, B.-E., Wright, A., Vanderbilt, C., & Cobb, M. H. (2001) · Chemical Reviews · doi:10.1021/cr000241p · Cited by 788
Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions
Francis, S. H., Blount, M. A., & Corbin, J. D. (2011) · Physiological Reviews · doi:10.1152/physrev.00030.2010 · Cited by 639
RAF-MEK-ERK pathway in cancer evolution and treatment
Ullah, R., Yin, Q., Snell, A. H., & Wan, L. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.010 · Cited by 553
mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module
Dodge, K. L. (2001) · The EMBO Journal · doi:10.1093/emboj/20.8.1921 · Cited by 507
Cyclic AMP-specific PDE4 Phosphodiesterases as Critical Components of Cyclic AMP Signaling
Conti, M., Richter, W., Mehats, C., Livera, G., Park, J.-Y., & Jin, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r200029200 · Cited by 481
Metadata
- Authors
- Hoffmann, R., Baillie, G. S., MacKenzie, S. J., Yarwood, S. J., & Houslay, M. D.
- Venue
- The EMBO Journal
- Published
- 1999-02-15
- Volume
- 18
- Issue
- 4
- Pages
- 893-903
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- OpenAlex
- W1996571204
- Cited by
- 270
- References
- 47
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579. https://app.cochat.ai/papers/10.1093/emboj/18.4.893
- The paper
- Hoffmann, R., Baillie, G. S., MacKenzie, S. J., Yarwood, S. J., & Houslay, M. D. (1999). The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579. The EMBO Journal. https://doi.org/10.1093/emboj/18.4.893
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
