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Cited by 190

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Three‐dimensional structure of the bacterial multidrug transporter EmrE shows it is an asymmetric homodimer

Ubarretxena‐Belandia, Iban, Baldwin, Joyce M., Schuldiner, Shimon, Tate, Christopher G.·2003·The EMBO Journal
DOI 10.1093/emboj/cdg611
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Crossref · 10.1093/emboj/cdg611

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  • Dual-topology dimeric construction is known in small multidrug transporters but has not been previously observed in ion channels.

    “Dual-topology dimeric construction is known in small multidrug transporters9–11 but has not been previously observed in ion channels.”

    From Crystal structures of a double-barrelled fluoride ion channel (2015) · cites this paper as [9]

  • Such a dual topology architecture is exceedingly rare among membrane proteins, and has only been structurally confirmed for two other transporter classes.

    “Such an architecture is exceedingly rare among membrane proteins, and has only been structurally confirmed for two other transporter classes (71, 72).”

    From Membrane exporters of fluoride ion (2021) · cites this paper as [71]

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Research works printed but not linked: 36

  1. Abramson J, Smirnova I, Kasho V, Verner G, Kaback HR and Iwata S (2003) Structure and mechanism of the lactose permease of Escherichia coli. Science, 301, 610–615. · DOI
  2. Arkin IT, Russ WP, Lebendiker M and Schuldiner S (1996) Determining the secondary structure and orientation of EmrE, a multi‐drug transporter, indicates a transmembrane four‐helix bundle. Biochemistry, 35, 7233–7238. · DOI
  3. Chang G (2003) Structure of MsbA from Vibrio cholera: a multidrug resistance ABC transporter homolog in a closed conformation. J Mol Biol, 330, 419–430. · DOI
  4. Chang G and Roth CB (2001) Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters. Science, 293, 1793–1800. · DOI
  5. Cizman M (2003) The use and resistance to antibiotics in the community. Int J Antimicrob Agents, 21, 297–307. · DOI
  6. Crowther RA, Henderson R and Smith JM (1996) MRC image processing programs. J Struct Biol, 116, 9–16. · DOI
  7. Dunlop J, Jones PC and Finbow ME (1995) Membrane insertion and assembly of ductin: a polytopic channel with dual orientations. EMBO J, 14, 3609–3616. · DOI
  8. Dutzler R, Campbell EB, Cadene M, Chait BT and MacKinnon R (2002) X‐ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity. Nature, 415, 287–294. · DOI · Paper page
  9. Elkins CA and Nikaido H (2003) 3D structure of AcrB: the archetypal multidrug efflux transporter of Escherichia coli likely captures substrates from periplasm. Drug Resist Updat, 6, 9–13. · DOI
  10. Fu D, Libson A, Miercke LJ, Weitzman C, Nollert P, Krucinski J and Stroud RM (2000) Structure of a glycerol‐conducting channel and the basis for its selectivity. Science, 290, 481–486. · DOI
  11. Gafvelin G and von Heijne G (1994) Topological ‘frustration’ in multispanning E. coli inner membrane proteins. Cell, 77, 401–412. · DOI
  12. Hirai T, Heymann JAW, Shi D, Sarker R, Maloney PC and Subramaniam S (2002) Three‐dimensional structure of a bacterial oxalate transporter. Nat Struct Biol, 9, 597–600.
  13. Huang Y, Lemieux MJSJ, Auer M and Wang D‐N (2003) Structure and mechanism of the glycerol‐3‐phosphate transporter from Escherichia coli. Science, 301, 616–620. · DOI
  14. Jones TA, Zou JY, Cowan SW and Kjeldgaard M (1991) Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A, 47, 110–119. · DOI
  15. Koteiche HA, Reeves MD and McHaourab HS (2003) Structure of the substrate binding pocket of the multidrug transporter EmrE: site‐directed spin labeling of transmembrane segment 1. Biochemistry, 42, 6099–6105. · DOI
  16. Kunji ER, von Gronau S, Oesterhelt D and Henderson R (2000) The three‐dimensional structure of halorhodopsin to 5 Å by electron crystallography: a new unbending procedure for two‐dimensional crystals by using a global reference structure. Proc Natl Acad Sci USA, 97, 4637–4642. · DOI
  17. Lebendiker M and Schuldiner S (1996) Identification of residues in the translocation pathway of EmrE, a multidrug antiporter from Escherichia coli. J Biol Chem, 271, 21193–21199. · DOI
  18. Locher KP, Lee AT and Rees DC (2002) The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism. Science, 296, 1091–1098. · DOI
  19. Mordoch SS, Granot D, Lebendiker M and Schuldiner S (1999) Scanning cysteine accessibility of EmrE, an H+‐coupled multidrug transporter from Escherichia coli, reveals a hydrophobic pathway for solutes. J Biol Chem, 274, 19480–19486. · DOI
  20. Murakami S, Nakashima R, Yamashita E and Yamaguchi A (2002) Crystal structure of bacterial multidrug efflux transporter AcrB. Nature, 419, 587–593. · DOI
  21. Muth TR and Schuldiner S (2000) A membrane‐embedded glutamate is required for ligand binding to the multidrug transporter EmrE. EMBO J, 19, 234–240. · DOI
  22. Nilsson I and von Heijne G (1990) Fine‐tuning the topology of a polytopic membrane protein: role of positively and negatively charged amino acids. Cell, 62, 1135–1141. · DOI
  23. Paulsen IT, Skurray RA, Tam R, Saier MH,Jr, Turner RJ, Weiner JH, Goldberg EB and Grinius LL (1996) The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs. Mol Microbiol, 19, 1167–1175. · DOI
  24. Rotem D, Sal‐man N and Schuldiner S (2001) In vitro monomer swapping in EmrE, a multidrug transporter from Escherichia coli, reveals that the oligomer is the functional unit. J Biol Chem, 276, 48243–48249. · DOI
  25. Schuldiner S, Granot D, Mordoch SS, Ninio S, Rotem D, Soskin M, Tate CG and Yerushalmi H (2001) Small is mighty: EmrE, a multidrug transporter as an experimental paradigm. News Physiol Sci, 16, 130–134.
  26. Schwaiger M, Lebendiker M, Yerushalmi H, Coles M, Groger A, Schwarz C, Schuldiner S and Kessler H (1998) NMR investigation of the multidrug transporter EmrE, an integral membrane protein. Eur J Biochem, 254, 610–619. · DOI
  27. Soskine M, Steiner‐Mordoch S and Schuldiner S (2002) Crosslinking of membrane‐embedded cysteines reveals contact points in the EmrE oligomer. Proc Natl Acad Sci USA, 99, 12043–12048. · DOI
  28. Tate CG, Kunji ER, Lebendiker M and Schuldiner S (2001) The projection structure of EmrE, a proton‐linked multidrug transporter from Escherichia coli, at 7 Å resolution. EMBO J, 20, 77–81. · DOI
  29. Tate CG, Ubarretxena‐Belandia I and Baldwin JM (2003) Conformational changes in the multidrug transporter EmrE associated with substrate binding. J Mol Biol, 332, 229–242. · DOI
  30. vonHeijne G (1986) The distribution of positively charged residues in bacterial inner membrane proteins correlates with the trans‐membrane topology. EMBO J, 5, 3021–3027. · DOI
  31. Wang J, Smerdon SJ, Jager J, Kohlstaedt LA, Rice PA, Friedman JM and Steitz TA (1994) Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer. Proc Natl Acad Sci USA, 91, 7242–7246. · DOI · Paper page
  32. Wise R, Hart T, Cars O, Streulens M, Helmuth R, Huovinen P and Sprenger M (1998) Antimicrobial resistance. Is a major threat to public health. Br Med J, 317, 609–610. · DOI
  33. Yerushalmi H and Schuldiner S (2000) A model for coupling of H(+) and substrate fluxes based on ‘time‐sharing’ of a common binding site. Biochemistry, 39, 14711–14719. · DOI
  34. Yerushalmi H, Lebendiker M and Schuldiner S (1995) EmrE, an Escherichia coli 12‐kDa multidrug transporter, exchanges toxic cations and H+ and is soluble in organic solvents. J Biol Chem, 270, 6856–6863. · DOI
  35. Yerushalmi H, Lebendiker M and Schuldiner S (1996) Negative dominance studies demonstrate the oligomeric structure of EmrE, a multidrug antiporter from Escherichia coli. J Biol Chem, 271, 31044–31048. · DOI
  36. Zgurskaya HI and Nikaido H (2002) Mechanistic parallels in bacterial and human multidrug efflux transporters. Curr Protein Pept Sci, 3, 531–540. · DOI

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Metadata

Authors
Ubarretxena‐Belandia, I., Baldwin, J. M., Schuldiner, S., & Tate, C. G.
Venue
The EMBO Journal
Publisher
Springer Science and Business Media LLC
Published
2003-12-01
Volume
22
Issue
23
Pages
6175-6181
ISSN
  • 0261-4189
  • 1460-2075
DOI
10.1093/emboj/cdg611
Cited by
190
References
2
Language
en
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