The DOI matches its Crossref record.
Humoral immune response against contractile proteins (actin and myosin) during cardiovascular disease
Abstract
Sensitive and highly specific ELISA assays were developed to determine humoral immune response against actin and myosin in 122 patients suffering from various cardiovascular diseases: acute viral myocarditis (n = 10, MYO), acute myocardial infarction (n = 28, AMI), valve surgery (n = 35, VALVE), coronary bypass surgery (n = 35, CABG), and peripheral vascular surgery (n = 14, VASC). Anti-actin and anti-myosin antibodies were determined on admission and serially during a period of 90 days. Anti-actin and anti-myosin immune response (IgG, IgM) was expressed comparing absorbance of the patients' serum with a reference serum. In the different patient groups significantly (P less than 0.01) higher anti-actin and anti-myosin antibody concentrations were found on admission compared with age-matched control groups. During follow-up, all patient groups except the vascular surgery group showed a significant immune response against actin and myosin, with an immune response ratio (peak/admission) for AMA IgG and IgM respectively of 2.12 and 2.40 in the VALVE group, 1.30 and 1.99 in the CABG group, 1.42 and 1.48 in the AMI group and 1.66 and 1.25 in the MYO group; and for AAA IgG and IgM respectively of 1.57 and 3.00 in the VALVE group, 1.54 and 1.64 in the CABG group, 1.25 and 1.07 in the AMI group, and 1.42 and 1.42 in the MYO group. A significant correlation between pre-cardiac injury and peak post-cardiac injury anti-myosin and anti-actin autoantibody levels could be demonstrated sugge…
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Autoantibodies targeting heart antigens are present in patients with viral myocarditis.
“numerous clinical studies have reported the presence of autoantibodies targeting heart antigens in patients with viral myocarditis”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [17]
Elevated levels of antimyosin autoantibodies are present in the serum of myocarditis patients and murine models, as well as in other cardiovascular disease conditions.
“an elevated level of antimyosin autoantibodies in the serum of both myocarditis patients and murine models, as well as in other cardiovascular disease conditions”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [17]
In earlier studies, autoantibodies targeting heart antigens have been identified in both myocarditis patients and animal models, regardless of the underlying cause-viral infections or existing autoimmune conditions.
“In earlier studies, autoantibodies targeting heart antigens have been identified in both myocarditis patients and animal models, regardless of the underlying cause-viral infections or existing autoimmune conditions. 15-18,57,189,190,218”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [17]
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Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51
Genetic control of autoimmune myocarditis mediated by myosin-specific antibodies
Kuan, A. P., Chamberlain, W., Malkiel, S., Lieu, H. D., Factor, S. M., Diamond, B., & Kotzin, B. L. (1999) · Immunogenetics · doi:10.1007/s002510050466 · Cited by 38
Metadata
- Authors
- De Scheerder, I. K., De Buyzere, M., Delanghe, J., Maas, A., Clement, D. L., & Wieme, R.
- Affiliations
- Ghent University Hospital (BE)
- ORCID
- Delanghe, J.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 1991-08-02
- Volume
- 12
- Issue
- suppl D
- Pages
- 88-94
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2009589619
- Cited by
- 43
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2014: 1 · 2012: 1
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
- Keywords
- anti-actin antibodies, anti-myosin antibodies, humoral immune response, autoantibodies, cardiovascular disease, myocardial infarction, viral myocarditis, valve surgery, coronary artery bypass grafting, peripheral vascular surgery, cardiac injury, IgG, IgM
- MeSH terms
- Actins, Aged, Autoantibodies, Enzyme-Linked Immunosorbent Assay, Female, Heart Diseases, Cardiac Surgical Procedures, Humans, Male, Middle Aged, Myocardial Infarction, Myocarditis, Myosins
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