The DOI matches its Crossref record; 187 of the 187 references it cites were found in a registry or an index.
Is atrial fibrillation an inflammatory disorder?
Abstract
There is mounting evidence to support the influence of inflammation in the pathogenesis of atrial fibrillation (AF). Indeed, AF is associated with increased levels of known inflammatory markers, even after adjustment for confounding factors. The renin-angiotensin-aldosterone system (RAAS) appears to play a key role in this process. Atrial biopsies from patients with AF have also confirmed the presence of inflammation. Furthermore, there is preliminary evidence to support a number of drug therapies that have the potential to reduce the clinical burden of AF. In this review, we present an overview of the evidence supporting a link between inflammation and AF, and some of the drug therapies, such as the angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, steroids, fish oils, and vitamin C, that might be efficacious in the prevention of AF by modulating inflammatory pathways.
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Inflammation and Atherosclerosis
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Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia
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Impact of Atrial Fibrillation on the Risk of Death: The Framingham Heart Study
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Atrial Remodeling and Atrial Fibrillation: Mechanisms and Implications
Nattel, S., Burstein, B., & Dobrev, D. (2008) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.107.754564 · Cited by 1,124
Mechanisms of thrombogenesis in atrial fibrillation: Virchow's triad revisited
Watson, T., Shantsila, E., & Lip, G. Y. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60040-4 · Cited by 1,123
Self-citationAdverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
Herrmann, J. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0348-1 · Cited by 747
The role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillation
Korantzopoulos, P., Kolettis, T. M., Galaris, D., & Goudevenos, J. A. (2007) · International Journal of Cardiology · doi:10.1016/j.ijcard.2006.04.026 · Cited by 335
Biomarkers in atrial fibrillation: a clinical review
Hijazi, Z., Oldgren, J., Siegbahn, A., Granger, C. B., & Wallentin, L. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht024 · Cited by 298
Metadata
- Authors
- Boos, C. J., Anderson, R. A., & Lip, G. Y. H.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-11-08
- Volume
- 27
- Issue
- 2
- Pages
- 136-149
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2110642473
- Cited by
- 552
- References
- 187
- FWCI
- 20.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Boos, C. J., Anderson, R. A., & Lip, G. Y. H. (2006). Is atrial fibrillation an inflammatory disorder? European Heart Journal. https://doi.org/10.1093/eurheartj/ehi645
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
