Vascular abnormalities in primary amyloidosis
Abstract
AIMS: Primary amyloidosis (AL) is a systemic disease; however, there is limited information regarding the presence and character of vascular abnormalities. METHODS AND RESULTS: Validated ultrasound techniques were used to prospectively determine carotid artery intimal-medial thickness (IMT) and brachial artery flow-mediated dilatation (FMD) in 59 consecutive AL patients and 17 age-similar, healthy, asymptomatic volunteers (CON). Carotid IMT was increased in AL when compared with CON (0.07 +/- 0.02 vs. 0.04 +/- 0.01 mm, P < 0.01). Similarly, brachial artery FMD was significantly lower in AL when compared with CON subjects (3 +/- 7 vs. 12 +/- 8%, P < 0.01). Multivariable analysis revealed that AL was associated with larger IMT and lower FMD after controlling for several confounding variables. However, within AL cases, there was not a significant association of cardiac vs. non-cardiac involvement with IMT or FMD (P = 0.1 and 0.2, respectively). CONCLUSION: AL is associated with abnormal vascular morphology and endothelial dysfunction. Vascular abnormalities do not appear to be related to echocardiographic evidence of cardiac involvement.
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Data on the risk of atherosclerosis in individuals with HDL-C-lowering mutations are contradictory.
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From HDL cholesterol: reappraisal of its clinical relevance (2017) · cites this paper as [30]
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References 32 · Cited by 65
Research works printed but not linked: 1
- Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, Lloyd JK, Deanfield JE. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340:1111-1115.
- Authors
- Modesto, K. M., Dispenzieri, A., Gertz, M., Cauduro, S. A., Khandheria, B. K., Seward, J. B., Kyle, R., Wood, C. M., Bailey, K. R., Tajik, A. J., Miller, F. A., Pellikka, P. A., & Abraham, T. P.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Abraham, T. P.
- ORCID
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-04-02
- Volume
- 28
- Issue
- 8
- Pages
- 1019-1024
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2134368433
- Cited by
- 65
- References
- 32
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 9 · 2021: 6 · 2020: 3 · 2019: 6 · 2018: 1 · 2017: 6 · 2016: 4 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL076513-02, R21HL076513)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Amyloidosis: Diagnosis, Treatment, Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac tumors and thrombi
- Keywords
- AL amyloidosis, vascular anomalies, carotid intima-media thickness, flow-mediated dilation, endothelial dysfunction, brachial artery, cardiac involvement, amyloidosis
- MeSH terms
- Aged, Amyloidosis, Brachial Artery, Carotid Arteries, Dilatation, Pathologic, Endothelium, Vascular, Female, Humans, Male, Prospective Studies, Ultrasonography, Vascular Diseases, Tunica Intima
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