The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Pulmonary vascular resistance and compliance stay inversely related during treatment of pulmonary hypertension
Open accessAbstract
AIMS: Pulmonary arterial compliance (C) is increasingly being recognized as an important contributor to right ventricular afterload, but for monitoring of treatment of pulmonary hypertension (PH) most often still only pulmonary vascular resistance (R) is used. We aimed at testing the hypothesis that R and C are coupled during treatment of PH and that substantial changes in both R and C would result in more haemodynamic improvement than changes in R alone. METHODS AND RESULTS: Data were analysed of two right-heart catheterizations of 52 patients with pulmonary arterial hypertension and 10 with chronic-thromboembolic PH. The product of R and C (= stroke volume over pulse pressure) did not change during therapy (P = 0.320), implying an inverse relationship. Changes in cardiac index correlated significantly (P < 0.001) with changes in R (R(2) = 0.37), better with changes in C (R(2) = 0.66), and best with changes in both (R(2) = 0.74). CONCLUSION: During therapy for PH, R and C remain inversely related. Therefore, changes in both R and C better explain changes in cardiac index than either of them alone. Not only resistance but also compliance plays a prominent role in PH especially in an early stage of the disease.
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Citations
Cites
McDonald's Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles
Vlachopoulos, C., O'Rourke, M., & Nichols, W. W. (2011) · doi:10.1201/b13568 · Cited by 1,613
Cited by
van de Veerdonk, M. C., Kind, T., Marcus, J. T., Mauritz, G.-J., Heymans, M. W., Bogaard, H.-J., Boonstra, A., Marques, K. M. J., Westerhof, N., & Vonk-Noordegraaf, A. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.068 · Cited by 846
Self-citationExercise-Induced Pulmonary Arterial Hypertension
Tolle, J. J., Waxman, A. B., Van Horn, T. L., Pappagianopoulos, P. P., & Systrom, D. M. (2008) · Circulation · doi:10.1161/circulationaha.108.787101 · Cited by 357
Metadata
- Authors
- Lankhaar, J.-W., Westerhof, N., Faes, T. J. C., Tji-Joong Gan, C., Marques, K. M., Boonstra, A., van den Berg, F. G., Postmus, P. E., & Vonk-Noordegraaf, A.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-06-13
- Volume
- 29
- Issue
- 13
- Pages
- 1688-1695
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2019902644
- Cited by
- 283
- References
- 1
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lankhaar, J.-W., Westerhof, N., Faes, T. J. C., Tji-Joong Gan, C., Marques, K. M., Boonstra, A., van den Berg, F. G., Postmus, P. E., & Vonk-Noordegraaf, A. (2008). Pulmonary vascular resistance and compliance stay inversely related during treatment of pulmonary hypertension. European Heart Journal. https://doi.org/10.1093/eurheartj/ehn103
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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