The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Effects of valsartan on morbidity and mortality in uncontrolled hypertensive patients with high cardiovascular risks: KYOTO HEART Study
Abstract
AIMS: The objective was to assess the add-on effect of valsartan on top of the conventional treatment for high-risk hypertension in terms of the morbidity and mortality. METHODS AND RESULTS: The KYOTO HEART Study was of a multicentre, Prospective Randomised Open Blinded Endpoint (PROBE) design, and the primary endpoint was a composite of fatal and non-fatal cardiovascular events (clintrials.gov NCT00149227). A total of 3031 Japanese patients (43% female, mean 66 years) with uncontrolled hypertension were randomized to either valsartan add-on or non-ARB treatment. Median follow-up period was 3.27 years. In both groups, blood pressure at baseline was 157/88 and 133/76 mmHg at the end of study. Compared with non-ARB arm, valsartan add-on arm had fewer primary endpoints (83 vs. 155; HR 0.55, 95% CI 0.42-0.72, P = 0.00001). CONCLUSION: Valsartan add-on treatment to improve blood pressure control prevented more cardiovascular events than conventional non-ARB treatment in high-risk hypertensive patients in Japan. These benefits cannot be entirely explained by a difference in blood pressure control.
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(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663
Brenner, B. M., Cooper, M. E., de Zeeuw, D., Keane, W. F., Mitch, W. E., Parving, H.-H., Remuzzi, G., Snapinn, S. M., Zhang, Z., & Shahinfar, S. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011161 · Cited by 7,493
Body-Mass Index and Mortality in a Prospective Cohort of U.S. Adults
Calle, E. E., Thun, M. J., Petrelli, J. M., Rodriguez, C., & Heath, C. W. (1999) · New England Journal of Medicine · doi:10.1056/nejm199910073411501 · Cited by 3,643
A Randomized Trial of the Angiotensin-Receptor Blocker Valsartan in Chronic Heart Failure
Cohn, J. N., & Tognoni, G. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010713 · Cited by 3,108
Angiotensin-Converting Enzyme Inhibitors
Brown, N. J., & Vaughan, D. E. (1998) · Circulation · doi:10.1161/01.cir.97.14.1411 · Cited by 958
Tanizaki, Y., Kiyohara, Y., Kato, I., Iwamoto, H., Nakayama, K., Shinohara, N., Arima, H., Tanaka, K., Ibayashi, S., & Fujishima, M. (2000) · Stroke · doi:10.1161/01.str.31.11.2616 · Cited by 346
Cited by
Bangalore, S., Kumar, S., Kjeldsen, S. E., Makani, H., Grossman, E., Wetterslev, J., Gupta, A. K., Sever, P. S., Gluud, C., & Messerli, F. H. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70260-6 · Cited by 353
Metadata
- Authors
- Sawada, T., Yamada, H., Dahlof, B., Matsubara, H., & for the KYOTO HEART Study Group
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-08-31
- Volume
- 30
- Issue
- 20
- Pages
- 2461-2469
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2097245721
- Cited by
- 167
- References
- 6
- FWCI
- 19.18
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- closed
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- Sawada, T., Yamada, H., Dahlof, B., Matsubara, H., & for the KYOTO HEART Study Group. (2009). Effects of valsartan on morbidity and mortality in uncontrolled hypertensive patients with high cardiovascular risks: KYOTO HEART Study. European Heart Journal. https://doi.org/10.1093/eurheartj/ehp363
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