The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A novel clinical method for quantification of regional left ventricular pressure–strain loop area: a non-invasive index of myocardial work
Open accessAbstract
AIMS: Left ventricular (LV) pressure-strain loop area reflects regional myocardial work and metabolic demand, but the clinical use of this index is limited by the need for invasive pressure. In this study, we introduce a non-invasive method to measure LV pressure-strain loop area. METHODS AND RESULTS: Left ventricular pressure was estimated by utilizing the profile of an empiric, normalized reference curve which was adjusted according to the duration of LV isovolumic and ejection phases, as defined by timing of aortic and mitral valve events by echocardiography. Absolute LV systolic pressure was set equal to arterial pressure measured invasively in dogs (n = 12) and non-invasively in patients (n = 18). In six patients, myocardial glucose metabolism was measured by positron emission tomography (PET). First, we studied anaesthetized dogs and observed an excellent correlation (r = 0.96) and a good agreement between estimated LV pressure-strain loop area and loop area by LV micromanometer and sonomicrometry. Secondly, we validated the method in patients with various cardiac disorders, including LV dyssynchrony, and confirmed an excellent correlation (r = 0.99) and a good agreement between pressure-strain loop areas using non-invasive and invasive LV pressure. Non-invasive pressure-strain loop area reflected work when incorporating changes in local LV geometry (r = 0.97) and showed a strong correlation with regional myocardial glucose metabolism by PET (r = 0.81). CONCLUSIONS: The novel non-invasive method for regional LV pressure-strain loop area corresponded well with invasive measurements and with directly measured myocardial work and it reflected myocardial metabolism. This method for assessment of regional work may be of clinical interest for several patients groups, including LV dyssynchrony and ischaemia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
RV myocardial work indices have shown an important correlation with invasive indices of RV systolic function and prognostic value, especially in patients with pulmonary hypertension.
“Although RV MW indices have shown an important correlation with invasive indices of RV systolic function and prognostic value, especially in patients with pulmonary hypertension [28,33], their role in TOF still needs to be investigated.”
From Multimodality imaging assessment of tetralogy of Fallot: From diagnosis to long-term follow-up (2023) · cites this paper as [28]
The Methods and results passage reports correlation between non-invasive and invasive measurements of left ventricular pressure–strain loop area, not right ventricular systolic function. The Clinical study and Conclusions passages likewise concern the left ventricle; searches for right ventricular myocardial work, pulmonary hypertension, and prognostic value found no passage addressing the attributed claim. Page numbers were not available in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measuredRV free-wall and global longitudinal strain showed less load dependency compared with conventional indices, but are still affected by pulmonary pressures and therefore RV afterload.
“Regarding RV systolic function, even though RV free-wall and GLS showed less load dependency compared with conventional indices, they are still affected by pulmonary pressures and therefore RV afterload [28].”
From Multimodality imaging assessment of tetralogy of Fallot: From diagnosis to long-term follow-up (2023) · cites this paper as [28]
The Introduction and Discussion address left ventricular strain and pressure–strain loop area, not right ventricular free-wall or global longitudinal strain. A search for RV strain, load dependency, pulmonary pressures, and RV afterload found no passage in our copy addressing the attributed comparison or afterload effect. Page numbers were not available in the indexed passages. (LLM, conf=0.76)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Agreement Between Methods of Measurement with Multiple Observations Per Individual
Bland, J. M., & Altman, D. G. (2007) · Journal of Biopharmaceutical Statistics · doi:10.1080/10543400701329422 · Cited by 1,864 · cited 1×
“account for multiple measurements from each animal or patient when using the Bland–Altman plots, we display reference intervals based on agreement between methods of measurement with multiple observations per individual.(10) For multiple comparisons, we used two-way repeated-measurements ANOVA with least significant d…”
Method
Flagged first, then by citations
Research works printed but not linked: 17
- 1979, Total mechanical energy of a ventricle model and cardiac oxygen consumption, Am J Physiol, 236, H498
- 1992, Assessment of myocardial oxygen consumption (Vo2) and systolic pressure–volume area (PVA) in human hearts, Eur Heart J, 13, 85
- 1987, Correlation of force–length area with oxygen consumption in ferret papillary muscle, Circ Res, 61, 318, 10.1161/01.RES.61.3.318 · DOI
- 1974, An analysis of segmental ischemic dysfunction utilizing the pressure–length loop, Circulation, 49, 748, 10.1161/01.CIR.49.4.748 · DOI
- 1974, Pressure–length loop: a new method for simultaneous measurement of segmental and total cardiac function, J Appl Physiol, 37, 771, 10.1152/jappl.1974.37.5.771 · DOI
- 1994, Regional fibre stress-fibre strain area as an estimate of regional blood flow and oxygen demand in the canine heart, J Physiol, 477, 481
- 2005, Regional myocardial work by strain Doppler echocardiography and LV pressure: a new method for quantifying myocardial function, Am J Physiol Heart Circ Physiol, 288, H2375, 10.1152/ajpheart.00946.2004 · DOI
- 2011, Mechanisms of abnormal systolic motion of the interventricular septum during left bundle-branch block, Circ Cardiovasc Imaging, 4, 264, 10.1161/CIRCIMAGING.110.961417 · DOI
- 1997, A simplified intravenous glucose loading protocol for fluorine-18 fluorodeoxyglucose cardiac single-photon emission tomography, Eur J Nucl Med, 24, 1291, 10.1007/s002590050154 · DOI
- 1988, Integrated regional work equals total left ventricular work in regionally ischemic canine heart, Am J Physiol Heart Circ Physiol, 254, H894, 10.1152/ajpheart.1988.254.5.H894 · DOI
- 1999, Mapping of regional myocardial strain and work during ventricular pacing: experimental study using magnetic resonance imaging tagging, J Am Coll Cardiol, 33, 1735, 10.1016/S0735-1097(99)00068-6 · DOI
- 2002, Postsystolic shortening in ischemic myocardium: active contraction or passive recoil?, Circulation, 106, 718, 10.1161/01.CIR.0000024102.55150.B6 · DOI
- 2009, Myocardial glucose and lactate metabolism during rest and atrial pacing in humans, J Physiol, 587, 2087
- 2003, Cardiac resynchronization therapy homogenizes myocardial glucose metabolism and perfusion in dilated cardiomyopathy and left bundle branch block, J Am Coll Cardiol, 41, 1523, 10.1016/S0735-1097(03)00257-2 · DOI
- 1995, Asymmetric thickness of the left ventricular wall resulting from asynchronous electric activation: a study in dogs with ventricular pacing and in patients with left bundle branch block, Am Heart J, 130, 1045, 10.1016/0002-8703(95)90207-4 · DOI
- 1998, Asynchronous electrical activation induces asymmetrical hypertrophy of the left ventricular wall, Circulation, 98, 588, 10.1161/01.CIR.98.6.588 · DOI
- 1990, Redistribution of myocardial fiber strain and blood flow by asynchronous activation, Am J Physiol, 259, H300
Cited by
Sorted by citations
Myocardial Work in Echocardiography
Marzlin, N., Hays, A. G., Peters, M., Kaminski, A., Roemer, S., O’Leary, P., Kroboth, S., Harland, D. R., Khandheria, B. K., Tajik, A. J., et al. (2023) · Circulation: Cardiovascular Imaging · doi:10.1161/circimaging.122.014419 · Cited by 121
Yedidya, I., Lustosa, R. P., Fortuni, F., van der Bijl, P., Namazi, F., Vo, N. M., Meucci, M. C., Ajmone Marsan, N., Bax, J. J., & Delgado, V. (2021) · Circulation: Cardiovascular Imaging · doi:10.1161/circimaging.120.012142 · Cited by 41
Minhas, A. S., Gilotra, N. A., Goerlich, E., Metkus, T., Garibaldi, B. T., Sharma, G., Bavaro, N., Phillip, S., Michos, E. D., & Hays, A. G. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.667721 · Cited by 34
Multimodality imaging assessment of tetralogy of Fallot: From diagnosis to long-term follow-up
Moscatelli, S., Pergola, V., Motta, R., Fortuni, F., Borrelli, N., Sabatino, J., Leo, I., Avesani, M., Montanaro, C., Surkova, E., et al. (2023) · Children · doi:10.3390/children10111747 · Cited by 17
Metadata
- Authors
- Russell, K., Eriksen, M., Aaberge, L., Wilhelmsen, N., Skulstad, H., Remme, E. W., Haugaa, K. H., Opdahl, A., Fjeld, J. G., Gjesdal, O., Edvardsen, T., & Smiseth, O. A.
- Affiliations
- Oslo University Hospital (NO)
- Corresponding author
- Smiseth, Otto A.
- ORCID
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-02-06
- Volume
- 33
- Issue
- 6
- Pages
- 724-733
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- PMC
- PMC3303715
- OpenAlex
- W2167096282
- Cited by
- 865
- References
- 1
- Citations by year
- 2026: 98 · 2025: 123 · 2024: 135 · 2023: 146 · 2022: 122 · 2021: 94 · 2020: 70 · 2019: 27 · 2018: 16 · 2017: 9 · 2016: 9 · 2015: 8 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- European Heart Journal (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Universitetet i Oslo
- Norges Forskningsråd
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- myocardial work, regional myocardial work, myocardial glucose metabolism, left ventricular dyssynchrony, left ventricular geometry, myocardial ischemia, sonomicrometry, dogs
- MeSH terms
- Aged, Animals, Bundle-Branch Block, Dogs, Echocardiography, Female, Glucose, Heart Rate, Hemodynamics, Humans, Male, Middle Aged, Myocardial Contraction, Myocardium, Reference Values, Stress, Physiological, Stroke Volume, Observer Variation, Ventricular Function, Left, Myocardial Ischemia, Ventricular Pressure, Positron-Emission Tomography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
