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Cited by 294

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Clinical outcomes of state-of-the-art percutaneous coronary revascularization in patients with de novo three vessel disease: 1-year results of the SYNTAX II study

Open access
Escaned, Javier, Collet, Carlos, Ryan, Nicola, Luigi De Maria, Giovanni, Walsh, Simon, Sabate, Manel, Davies, Justin, Lesiak, Maciej, Moreno, Raul, Cruz-Gonzalez, Ignacio, Hoole, Stephan P, Ej West, Nick, Piek, J J, Zaman, Azfar, Fath-Ordoubadi, Farzin, Stables, Rodney H, Appleby, Clare, van Mieghem, Nicolas, van Geuns, Robert Jm, Uren, Neal, Zueco, Javier, Buszman, Pawel, Iñiguez, Andres, Goicolea, Javier, Hildick-Smith, David, Ochala, Andrzej, Dudek, Dariusz, Hanratty, Colm, Cavalcante, Rafael, Kappetein, Arie Pieter, Taggart, David P, van Es, Gerrit-Anne, Morel, Marie-Angèle, de Vries, Ton, Onuma, Yoshinobu, Farooq, Vasim, Serruys, Patrick W, Banning, Adrian P·2017·European Heart Journal
DOI 10.1093/eurheartj/ehx512
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Abstract

Aims: To investigate if recent technical and procedural developments in percutaneous coronary intervention (PCI) significantly influence outcomes in appropriately selected patients with three-vessel (3VD) coronary artery disease. Methods and results: The SYNTAX II study is a multicenter, all-comers, open-label, single arm study that investigated the impact of a contemporary PCI strategy on clinical outcomes in patients with 3VD in 22 centres from four European countries. The SYNTAX-II strategy includes: heart team decision-making utilizing the SYNTAX Score II (a clinical tool combining anatomical and clinical factors), coronary physiology guided revascularisation, implantation of thin strut bioresorbable-polymer drug-eluting stents, intravascular ultrasound (IVUS) guided stent implantation, contemporary chronic total occlusion revascularisation techniques and guideline-directed medical therapy. The rate of major adverse cardiac and cerebrovascular events (MACCE [composite of all-cause death, cerebrovascular event, any myocardial infarction and any revascularisation]) at one year was compared to a predefined PCI cohort from the original SYNTAX-I trial selected on the basis of equipoise 4-year mortality between CABG and PCI. As an exploratory endpoint, comparisons were made with the historical CABG cohort of the original SYNTAX-I trial. Overall 708 patients were screened and discussed within the heart team; 454 patients were deemed appropriate to undergo PCI. At one year, the SYNTAX-II strategy was superior to the equipoise-derived SYNTAX-I PCI cohort (MACCE SYNTAX-II 10.6% vs. SYNTAX-I 17.4%; HR 0.58, 95% CI 0.39-0.85, P = 0.006). This difference was driven by a significant reduction in the incidence of MI (HR 0.27, 95% CI 0.11-0.70, P = 0.007) and revascularisation (HR 0.57, 95% CI 0.37-0.9, P = 0.015). Rates of all-cause death (HR 0.69, 95% CI 0.27-1.73, P = 0.43) and stroke (HR 0.69, 95% CI 0.10-4.89, P = 0.71) were similar. The rate of definite stent thrombosis was significantly lower in SYNTAX-II (HR 0.26, 95% CI 0.07-0.97, P = 0.045). Conclusion: At one year, clinical outcomes with the SYNTAX-II strategy were associated with improved clinical results compared to the PCI performed in comparable patients from the original SYNTAX-I trial. Longer term follow-up is awaited and a randomized clinical trial with contemporary CABG is warranted. ClinicalTrials.gov Identifier: NCT02015832.

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Authors
Escaned, J., Collet, C., Ryan, N., Luigi De Maria, G., Walsh, S., Sabate, M., Davies, J., Lesiak, M., Moreno, R., Cruz-Gonzalez, I., Hoole, S. P., Ej West, N., Piek, J. J., Zaman, A., Fath-Ordoubadi, F., Stables, R. H., Appleby, C., van Mieghem, N., van Geuns, R. J., Uren, N., Zueco, J., Buszman, P., Iñiguez, A., Goicolea, J., Hildick-Smith, D., Ochala, A., Dudek, D., Hanratty, C., Cavalcante, R., Kappetein, A. P., Taggart, D. P., van Es, G.-A., Morel, M.-A., de Vries, T., Onuma, Y., Farooq, V., Serruys, P. W., & Banning, A. P.
Venue
European Heart Journal
Publisher
Oxford University Press (OUP)
Published
2017-08-26
Volume
38
Issue
42
Pages
3124-3134
ISSN
  • 0195-668X (ISSN-L)
  • 1522-9645
DOI
10.1093/eurheartj/ehx512
OpenAlex
W2748053562
Cited by
294
References
28
FWCI
37.65
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Clinical outcomes of state-of-the-art percutaneous coronary revascularization in patients with de novo three vessel disease: 1-year results of the SYNTAX II study. https://app.cochat.ai/papers/10.1093/eurheartj/ehx512
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Escaned, J., Collet, C., Ryan, N., Luigi De Maria, G., Walsh, S., Sabate, M., Davies, J., Lesiak, M., Moreno, R., Cruz-Gonzalez, I., Hoole, S. P., Ej West, N., Piek, J. J., Zaman, A., Fath-Ordoubadi, F., Stables, R. H., Appleby, C., van Mieghem, N., van Geuns, R. J., . . . Banning, A. P. (2017). Clinical outcomes of state-of-the-art percutaneous coronary revascularization in patients with de novo three vessel disease: 1-year results of the SYNTAX II study. European Heart Journal. https://doi.org/10.1093/eurheartj/ehx512

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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