The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Annual number of candidates for transcatheter aortic valve implantation per country: current estimates and future projections
Open accessAbstract
Aims: The number of transcatheter aortic valve implantation (TAVI) procedures is rapidly increasing. This has a major impact on health care resource planning. However, the annual numbers of TAVI candidates per country are unknown. The aim of this study was to estimate current and future number of annual TAVI candidates in 27 European countries, the USA and Canada. Methods and results: Systematic literature searches and meta-analyses were performed on aortic stenosis (AS) epidemiology and decision-making in severe symptomatic AS. The incidence rate of severe AS was determined. Findings were combined with population statistics and integrated into a model employing Monte Carlo simulations to predict the annual number of TAVI candidates. Various future scenarios and sensitivity analyses were explored. Data from 37 studies (n = 26 402) informed the model. The calculated incidence rate of severe AS was 4.4‰/year [95% confidence interval (95% CI) 3.0-6.1‰] in patients ≥65 years. AS-related symptoms were present in 68.3% (95% CI 60.8-75.9%) of patients with severe AS. Despite having severe symptomatic AS, 41.6% (95% CI 36.9-46.3%) did not undergo surgical aortic valve replacement. Of the non-operated patients, 61.7% (95% CI 42.0-81.7%) received TAVI. The model predicted 114 757 (95% CI 69 380-172 799) European and 58 556 (95% CI 35 631-87 738) Northern-American TAVI candidates annually. Conclusion: Currently, approximately 180 000 patients can be considered potential TAVI candidates in the European Union and in Northern-America annually. This number might increase up to 270 000 if indications for TAVI expand to low-risk patients. These findings have major implications for health care resource planning in the 29 individual countries.
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Cites
Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients
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2017 ESC/EACTS Guidelines for the management of valvular heart disease
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Self-citationTranscatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients
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Self-citation2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease
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Self-citationTranscatheter Aortic-Valve Replacement with a Self-Expanding Prosthesis
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Cited by
2025 ESC/EACTS Guidelines for the management of valvular heart disease
Praz, F., Borger, M. A., Lanz, J., Marin-Cuartas, M., Abreu, A., Adamo, M., Ajmone Marsan, N., Barili, F., Bonaros, N., Cosyns, B., et al. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf194 · Cited by 1,072
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Next-generation tissue-engineered heart valves with repair, remodelling and regeneration capacity
Fioretta, E. S., Motta, S. E., Lintas, V., Loerakker, S., Parker, K. K., Baaijens, F. P. T., Falk, V., Hoerstrup, S. P., & Emmert, M. Y. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0422-8 · Cited by 262
Metadata
- Authors
- Durko, A. P., Osnabrugge, R. L., Van Mieghem, N. M., Milojevic, M., Mylotte, D., Nkomo, V. T., & Pieter Kappetein, A.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-03-12
- Volume
- 39
- Issue
- 28
- Pages
- 2635-2642
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2791935659
- Cited by
- 304
- References
- 39
- FWCI
- 26.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Durko, A. P., Osnabrugge, R. L., Van Mieghem, N. M., Milojevic, M., Mylotte, D., Nkomo, V. T., & Pieter Kappetein, A. (2018). Annual number of candidates for transcatheter aortic valve implantation per country: current estimates and future projections. European Heart Journal. https://doi.org/10.1093/eurheartj/ehy107
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