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Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study

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Habib, Gilbert, Erba, Paola Anna, Iung, Bernard, Donal, Erwan, Cosyns, Bernard, Laroche, Cécile, Popescu, Bogdan A, Prendergast, Bernard, Tornos, Pilar, Sadeghpour, Anita, Oliver, Leopold, Vaskelyte, Jolanta-Justina, Sow, Rouguiatou, Axler, Olivier, Maggioni, Aldo P, Lancellotti, Patrizio, EURO-ENDO Investigators, Gale, C P, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, Maggioni, A P, Nagy, V K, Nedoshivin, A, Petronio, A-S, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Habib, G, Lancellotti, P, Cosyns, B, Donal, E, Erba, P, Iung, B, Maggioni, A P, Popescu, B A, Prendergast, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Laroche, C, Missiamenou, V, Taylor, C, Ali Tatar-Chentir, N N, Al-Mallah, M, Astrom Aneq, M, Athanassopoulos, G, Badano, L P, Benyoussef, S, Calderon Aranda, E, Cardim, N M, Chan, K-L, Cosyns, B, Cruz, I, Edvardsen, T, Goliasch, G, Habib, G, Hagendorff, A, Hristova, K, Iung, 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L E, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, Sinan, U Y, Canpolat, U, Mutlu, B, Atas, H, Dervishova, R, Ileri, C, Alhashmi, J, Tahir, J, Zarger, P, Baslib, F, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, Ursi, M P, Cannata, S, Dworakowski, R, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, Asch, F M, Zemedkun, M, Alyavi, B, Uzokov, J·2019·European Heart Journal

Abstract

Aims: The EURO-ENDO registry aimed to study the management and outcomes of patients with infective endocarditis (IE). Methods and results: Prospective cohort of 3116 adult patients (2470 from Europe, 646 from non-ESC countries), admitted to 156 hospitals in 40 countries between January 2016 and March 2018 with a diagnosis of IE based on ESC 2015 diagnostic criteria. Clinical, biological, microbiological, and imaging [echocardiography, computed tomography (CT) scan, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)] data were collected. Infective endocarditis was native (NVE) in 1764 (56.6%) patients, prosthetic (PVIE) in 939 (30.1%), and device-related (CDRIE) in 308 (9.9%). Infective endocarditis was community-acquired in 2046 (65.66%) patients. Microorganisms involved were staphylococci in 1085 (44.1%) patients, oral streptococci in 304 (12.3%), enterococci in 390 (15.8%), and Streptococcus gallolyticus in 162 (6.6%). 18F-fluorodeoxyglucose positron emission tomography/computed tomography was performed in 518 (16.6%) patients and presented with cardiac uptake (major criterion) in 222 (42.9%) patients, with a better sensitivity in PVIE (66.8%) than in NVE (28.0%) and CDRIE (16.3%). Embolic events occurred in 20.6% of patients, and were significantly associated with tricuspid or pulmonary IE, presence of a vegetation and Staphylococcus aureus IE. According to ESC guidelines, cardiac surgery was indicated in 2160 (69.3%) patients, but finally performed in only 1596 (73.9%) of them. In-hospital death occurred in 532 (17.1%) patients and was more frequent in PVIE. Independent predictors of mortality were Charlson index, creatinine > 2 mg/dL, congestive heart failure, vegetation length > 10 mm, cerebral complications, abscess, and failure to undertake surgery when indicated. Conclusion: Infective endocarditis is still a life-threatening disease with frequent lethal outcome despite profound changes in its clinical, microbiological, imaging, and therapeutic profiles.

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Habib, G., Erba, P. A., Iung, B., Donal, E., Cosyns, B., Laroche, C., Popescu, B. A., Prendergast, B., Tornos, P., Sadeghpour, A., Oliver, L., Vaskelyte, J.-J., Sow, R., Axler, O., Maggioni, A. P., Lancellotti, P., EURO-ENDO Investigators, Gale, C. P., Beleslin, B., Budaj, A., Chioncel, O., Dagres, N., Danchin, N., Emberson, J., Erlinge, D., Glikson, M., Gray, A., Kayikcioglu, M., Maggioni, A. P., Nagy, V. K., Nedoshivin, A., Petronio, A.-S., Roos-Hesselink, J., Wallentin, L., Zeymer, U., Habib, G., Lancellotti, P., Cosyns, B., Donal, E., Erba, P., Iung, B., Maggioni, A. P., Popescu, B. A., Prendergast, B., Tornos, P., Andarala, M., Berle, C., Brunel-Lebecq, A., Fiorucci, E., Laroche, C., Missiamenou, V, Taylor, C., Ali Tatar-Chentir, N. N., Al-Mallah, M., Astrom Aneq, M., Athanassopoulos, G., Badano, L. P., Benyoussef, S., Calderon Aranda, E., Cardim, N. M., Chan, K.-L., Cosyns, B., Cruz, I., Edvardsen, T., Goliasch, G., Habib, G., Hagendorff, A., Hristova, K., Iung, B., Kamp, O., Kang, D.-H., Kong, W., Matskeplishvili, S., Meshaal, M., Mirocevic, M., Neskovic, A. N., Pazdernik, M., Plonska-Gosciniak, E., Popescu, B. A., Prendergast, B., Raissouni, M., Ronderos, R., Sade, L. E., Sadeghpour, A., Sambola, A., Sengupta, S., Separovic-Hanzevacki, J., Takeuchi, M., Tucay, E., Tude Rodrigues, A. C., Varga, A., Vaskelyte, J., Yamagata, K., Yiangou, K., Zaky, H., Granada, I., Mahia, M., Ressi, S., Nacinovich, F., Iribarren, A., Fernandez Oses, P., Avegliano, G., Filipini, E., Obregon, R., Bangher, M., Dho, J., Cartasegna, L., Plastino, M. L., Novas, V, Shigel, C., Reyes, G., De Santos, M., Gastaldello, N., Granillo Fernandez, M., Potito, M., Streitenberger, G., Velazco, P., Casabé, J. H., Cortes, C., Guevara, E., Salmo, F., Seijo, M., Weidinger, F., Heger, M., Brooks, R., Stöllberger, C., Ho, C.-Y., Perschy, L., Puskas, L., Binder, C., Rosenhek, R., Schneider, M., Winter, M.-P., Hoffer, E., Melissopoulou, M., Lecoq, E., Legrand, D., Jacquet, S., Massoz, M., Pierard, L., Marchetta, S., Dulgheru, R., Emal, C. D., Oury, C., Droogmans, S., Kerkhove, D., Plein, D., Soens, L., Weytjens, C., Motoc, A., Roosens, B., Lemoine, I., Rodrigus, I., Paelinck, B., Amsel, B., Unger, P., Konopnicki, D., Beauloye, C., Pasquet, A., Vanoverschelde, J. L., Pierard, S., Vancraeynest, D., Sinnaeve, F., Andrade, J. L., Staszko, K., Dos Santos Monteiro, R., Miglioranza, M. H., Shuha, D. L., Alcantara, M., Cravo, V, Fazzio, L., Felix, A., Iso, M., Musa, C., Siciliano, A. P., Villaca Filho, F., Rodrigues, A., Vilela, F., Braga, J., Silva, R., Rodrigues, D., Silva, L., Morhy, S., Fischer, C., Silva, R., Vieira, M., Afonso, T., Abreu, J., Falcao, S. N., Moises, V. A., Gouvea, A., Mancuso, F. J., Souza, A. C., Silva, C. Y., João, G., Abboud, C. S., Bellio de Mattos Barretto, R., Ramos, A., Arnoni, R., Assef, J. E., Della Togna, D. J., Le Bihan, D., Miglioli, L., Romero Oliveira, A. P., Tadeu Magro Kroll, R., Cortez, D., Gelape, C. L., Peirira Nunes, M. D. C., De Abreu Ferrari, T. C., Hay, K., Le, V, Page, M., Poulin, F., Sauve, C., Serri, K., Mercure, C., Beaudoin, J., Pibarot, P., Sebag, I. A., Rudski, L. 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Venue
European Heart Journal
Published
2019-09-03
Volume
40
Issue
39
Pages
3222-3232
ISSN
  • 0195-668X (ISSN-L)
  • 1522-9645
OpenAlex
W2972249741
Cited by
911
References
23
FWCI
50.51
Type
journal article
Language
en
Open access
bronze

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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This page
CoChat. (2026). Citation check: Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study. https://app.cochat.ai/papers/10.1093/eurheartj/ehz620
The paper
Habib, G., Erba, P. A., Iung, B., Donal, E., Cosyns, B., Laroche, C., Popescu, B. A., Prendergast, B., Tornos, P., Sadeghpour, A., Oliver, L., Vaskelyte, J.-J., Sow, R., Axler, O., Maggioni, A. P., Lancellotti, P., EURO-ENDO Investigators, Gale, C. P., Beleslin, B., . . . Uzokov, J. (2019). Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study. European Heart Journal. https://doi.org/10.1093/eurheartj/ehz620

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.