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Cited by 153Atrial Fibrillation Management and OutcomesCardiovascular Effects of ExercisePhysical Activity and Health

Emerging risk factors and the dose–response relationship between physical activity and lone atrial fibrillation: a prospective case–control study

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Calvo, Naiara, Ramos, Pablo, Montserrat, Silvia, Guasch, Eduard, Coll-Vinent, Blanca, Domenech, Mònica, Bisbal, Felipe, Hevia, Sara +10 more·2016·Europace
DOI 10.1093/europace/euv216PMC PMC4739323
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Abstract

AIMS: The role of high-intensity exercise and other emerging risk factors in lone atrial fibrillation (Ln-AF) epidemiology is still under debate. The aim of this study was to analyse the contribution of each of the emerging risk factors and the impact of physical activity dose in patients with Ln-AF. METHODS AND RESULTS: Patients with Ln-AF and age- and sex-matched healthy controls were included in a 2:1 prospective case-control study. We obtained clinical and anthropometric data transthoracic echocardiography, lifetime physical activity questionnaire, 24-h ambulatory blood pressure monitoring, Berlin questionnaire score, and, in patients at high risk for obstructive sleep apnoea (OSA) syndrome, a polysomnography. A total of 115 cases and 57 controls were enrolled. Conditional logistic regression analysis associated height [odds ratio (OR) 1.06 [1.01-1.11]], waist circumference (OR 1.06 [1.02-1.11]), OSA (OR 5.04 [1.44-17.45]), and 2000 or more hours of cumulative high-intensity endurance training to a higher AF risk. Our data indicated a U-shaped association between the extent of high-intensity training and AF risk. The risk of AF increased with an accumulated lifetime endurance sport activity ≥ 2,000 h compared with sedentary individuals (OR 3.88 [1.55-9.73]). Nevertheless, a history of <2000 h of high-intensity training protected against AF when compared with sedentary individuals (OR 0.38 [0.12-0.98]). CONCLUSION: A history of ≥ 2,000 h of vigorous endurance training, tall stature, abdominal obesity, and OSA are frequently encountered as risk factors in patients with Ln-AF. Fewer than 2000 total hours of high-intensity endurance training associates with reduced Ln-AF risk.

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Crossref · 10.1093/europace/euv216

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  • The prevalence of AF in competitive athletes ranges from 0.3% to approximately 13%, differing according to age and modality of exercise training.

    “The prevalence of AF in competitive athletes ranges from 0.3% to approximately 13%, and differs according to the age and the modality of exercise training [13,25,26,27].”

    From Atrial Fibrillation in Elite Athletes: A Comprehensive Review of the Literature (2024) · cites this paper as [27]

    The Results (Sport activity; page unavailable) report different AF odds for endurance versus team sports and an univariate association with age at the start of vigorous exercise. They do not report AF prevalence among competitive athletes or the claimed 0.3%–13% range; the case–control study’s percentages cannot establish population prevalence. (LLM, conf=0.83)

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Research works printed but not linked: 16

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Authors
Calvo, N., Ramos, P., Montserrat, S., Guasch, E., Coll-Vinent, B., Domenech, M., Bisbal, F., Hevia, S., Vidorreta, S., Borras, R., Falces, C., Embid, C., Montserrat, J. M., Berruezo, A., Coca, A., Sitges, M., Brugada, J., & Mont, L.
Affiliations
  • Hospital Clínic de Barcelona (ES)
  • Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
ORCID
Venue
Europace
Publisher
Oxford University Press (OUP)
Published
2015-09-01
Volume
18
Issue
1
Pages
57-63
ISSN
  • 1099-5129 (ISSN-L)
  • 1532-2092
DOI
10.1093/europace/euv216
PMC
PMC4739323
OpenAlex
W2342341993
Cited by
153
References
5
Citations by year
2026: 10 · 2025: 11 · 2024: 16 · 2023: 13 · 2022: 9 · 2021: 17 · 2020: 17 · 2019: 9 · 2018: 21 · 2017: 12 · 2016: 15 · 2015: 1 · 2012: 1
FWCI
11.89
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • EP Europace (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by-nc)
  • HighWire Press Open Archive (submittedVersion)
Funders
  • Hospital Clínic, University of Barcelona
  • Premi Fi de Residencia-Ajut a la Recerca Josep Font
  • Sociedad Española de Cardiologia
  • ‘Fundació per l'Estudi de la Hipertensió Arterial dels Hospitals Comarcals de Catalunya’ (FEHTACC)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
Keywords
lone atrial fibrillation, physical activity, dose-response relationship, obstructive sleep apnea, tall stature, abdominal obesity, waist circumference, risk factors, sedentary lifestyle
MeSH terms
Atrial Fibrillation, Female, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Spain, Sports, Exercise, Comorbidity, Incidence, Case-Control Studies, Exercise Tolerance, Sex Distribution, Sleep Apnea, Obstructive

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