The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Lyme borreliosis–from tick bite to diagnosis and treatment
Abstract
Lyme borreliosis is caused by certain genospecies of the Borrelia burgdorferi sensu lato complex, which are transmitted by hard ticks of the genus Ixodes. The most common clinical manifestation is erythema migrans, an expanding skin redness that usually develops at the site of a tick bite and eventually resolves even without antibiotic treatment. The infecting pathogens can spread to other tissues and organs, resulting in manifestations that can involve the nervous system, joints, heart and skin. Fatal outcome is extremely rare and is due to severe heart involvement; fetal involvement is not reliably ascertained. Laboratory support-mainly by serology-is essential for diagnosis, except in the case of typical erythema migrans. Treatment is usually with antibiotics for 2 to 4 weeks; most patients recover uneventfully. There is no convincing evidence for antibiotic treatment longer than 4 weeks and there is no reliable evidence for survival of borreliae in adequately treated patients. European Lyme borreliosis is a frequent disease with increasing incidence. However, numerous scientifically questionable ideas on its clinical presentation, diagnosis and treatment may confuse physicians and lay people. Since diagnosis of Lyme borreliosis should be based on appropriate clinical signs, solid knowledge of clinical manifestations is essential.
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Cites
Lyme Disease—a Tick-Borne Spirochetosis?
Burgdorfer, W., Barbour, A. G., Hayes, S. F., Benach, J. L., Grunwaldt, E., & Davis, J. P. (1982) · Science · doi:10.1126/science.7043737 · Cited by 2,859
Wormser, G. P., Dattwyler, R. J., Shapiro, E. D., Halperin, J. J., Steere, A. C., Klempner, M. S., Krause, P. J., Bakken, J. S., Strle, F., Stanek, G., et al. (2006) · Clinical Infectious Diseases · doi:10.1086/508667 · Cited by 2,087
Self-citationThe Spirochetal Etiology of Lyme Disease
Steere, A. C., Grodzicki, R. L., Kornblatt, A. N., Craft, J. E., Barbour, A. G., Burgdorfer, W., Schmid, G. P., Johnson, E., & Malawista, S. E. (1983) · New England Journal of Medicine · doi:10.1056/nejm198303313081301 · Cited by 1,573
Isolation and cultivation of Lyme disease spirochetes.
Barbour, A. G. (1984) · PubMed Central · Cited by 1,556
An epidemic of oligoarticular arthritis in children and adults in three connecticut communities
Steere, A. C., Malawista, S. E., Snydman, D. R., Shope, R. E., Andiman, W. A., Ross, M. R., & Steele, F. M. (1977) · Arthritis & Rheumatism · doi:10.1002/art.1780200102 · Cited by 1,239
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Self-citationSteere, A. C. (1989) · New England Journal of Medicine · doi:10.1056/nejm198908313210906 · Cited by 1,192
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Self-citationSpirochetes Isolated from the Blood of Two Patients with Lyme Disease
Benach, J. L., Bosler, E. M., Hanrahan, J. P., Coleman, J. L., Habicht, G. S., Bast, T. F., Cameron, D. J., Ziegler, J. L., Barbour, A. G., Burgdorfer, W., et al. (1983) · New England Journal of Medicine · doi:10.1056/nejm198303313081302 · Cited by 813
Cited by
Lyme disease in companion animals: an updated state-of-art and current situation in Portugal
Picado, R., Baptista, C. J., Meneses, A., Legatti, S., Fonseca, J., & Belas, A. (2024) · Veterinary Research Communications · doi:10.1007/s11259-024-10532-8 · Cited by 6
Metadata
- Authors
- Stanek, G., & Strle, F.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-02-23
- Volume
- 42
- Issue
- 3
- Pages
- 233-258
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W2790036875
- Cited by
- 265
- References
- 91
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
