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Cited by 180Bacterial Genetics and BiotechnologyGene Regulatory Network AnalysisMicrobial Metabolic Engineering and Bioproduction

Diversity, versatility and complexity of bacterial gene regulation mechanisms: opportunities and drawbacks for applications in synthetic biology.

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Bervoets, Indra, Charlier, Daniel·2019·FEMS Microbiology Reviews
DOI 10.1093/femsre/fuz001PMC PMC6524683
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Abstract

Gene expression occurs in two essential steps: transcription and translation. In bacteria, the two processes are tightly coupled in time and space, and highly regulated. Tight regulation of gene expression is crucial. It limits wasteful consumption of resources and energy, prevents accumulation of potentially growth inhibiting reaction intermediates, and sustains the fitness and potential virulence of the organism in a fluctuating, competitive and frequently stressful environment. Since the onset of studies on regulation of enzyme synthesis, numerous distinct regulatory mechanisms modulating transcription and/or translation have been discovered. Mostly, various regulatory mechanisms operating at different levels in the flow of genetic information are used in combination to control and modulate the expression of a single gene or operon. Here, we provide an extensive overview of the very diverse and versatile bacterial gene regulatory mechanisms with major emphasis on their combined occurrence, intricate intertwinement and versatility. Furthermore, we discuss the potential of well-characterized basal expression and regulatory elements in synthetic biology applications, where they may ensure orthogonal, predictable and tunable expression of (heterologous) target genes and pathways, aiming at a minimal burden for the host.

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Authors
Bervoets, I., & Charlier, D.
Affiliations
  • Vrije Universiteit Brussel (BE)
  • Research Group of Microbiology, Department of Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium
ORCID
Venue
FEMS Microbiology Reviews
Publisher
Oxford University Press (OUP)
Published
2019-02-04
Volume
43
Issue
3
Pages
304-339
ISSN
  • 0168-6445 (ISSN-L)
  • 1574-6976
DOI
10.1093/femsre/fuz001
PMC
PMC6524683
OpenAlex
W2912247112
Cited by
180
References
4
Citations by year
2026: 24 · 2025: 24 · 2024: 25 · 2023: 17 · 2022: 27 · 2021: 25 · 2020: 30 · 2019: 7 · 2017: 1
FWCI
2.95
Type
journal article
Language
en
Open access
Licence
Locations
  • FEMS Microbiology Reviews (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Funders
Fonds voor Wetenschappelijk Onderzoek Vlaanderen (G.0321.13 N)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Keywords
bacterial gene regulation, transcriptional regulation, translational regulation, operon regulation, synthetic biology, heterologous expression, resource allocation, virulence
MeSH terms
Bacteria, Genetic Variation, Gene Expression Regulation, Bacterial, Synthetic Biology

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