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Absence of Rtt109p, a fungal-specific histone acetyltransferase, results in improved acetic acid tolerance of Saccharomyces cerevisiae
Open accessAbstract
RTT109 is a histone acetyltransferase for the acetylation of histone H3. It is still not clear whether RTT109 plays a role in regulation of gene expression under environmental stresses. In this study, the involvement of RTT109 in acetic acid stress tolerance of Saccharomyces cerevisiae was investigated. It was revealed that the absence of RTT109 enhanced resistance to 5.5 g L(-1) acetic acid, which was indicated by improved growth of RTT109Δ mutant compared with that of the wild-type BY4741 strain. Meanwhile, the lag phase was shortened for 48 h and glucose consumption completed 36 h in advance for RTT109Δ mutant compared to the wild-type strain, with ethanol production rate increased from 0.39 to 0.60 g L(-1) h(-1). Significantly, elevated transcription levels of HSP12, CTT1 and GSH1, as well as increased activities of antioxidant enzymes were observed in RTT109Δ under acetic acid stress. Improved flocculation of RTT109Δ compared to that of the control strain BY4741 under the acetic acid stress was also observed. These results suggest that the absence of RTT109 not only activates transcription of stress responsive genes, but also improves resistance to oxidative stress, which ultimately contributes to improved acetic acid tolerance in S. cerevisiae.
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“In addition, regional and cultural factors may influence the acceptability and efficacy of certain exercise types, especially in non-Western populations where mind–body exercises are more commonly practiced (Cheng et al., 2016).”
From Optimal exercise interventions for enhancing cognitive function in older adults: a network meta-analysis (2025) · cites this paper as Cheng et al., 2016
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Cited by
Han, H., Zhang, J., Zhang, F., Li, F., & Wu, Z. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1510773 · Cited by 21
Metadata
- Authors
- Cheng, C., Zhao, X., Zhang, M., & Bai, F.
- Affiliations
- Dalian University of Technology (CN)
- ORCID
- Cheng, Cheng
- Venue
- FEMS Yeast Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-02-05
- Volume
- 16
- Issue
- 2
- Pages
- fow010
- ISSN
- 1567-1356 (ISSN-L)
- 1567-1364
- OpenAlex
- W2265161874
- Cited by
- 37
- References
- 0
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 1
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Yeast Research (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Natural Science Foundation of China (21376043, 51561145014, 31461143029)
- National High-tech Research and Development Program (2012AA101805)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Keywords
- Rtt109, histone acetyltransferase, histone H3 acetylation, acetic acid tolerance, Saccharomyces cerevisiae, stress tolerance, oxidative stress, antioxidant enzymes, flocculation, ethanol production, glucose utilization
- MeSH terms
- Drug Tolerance, Saccharomyces cerevisiae, Gene Expression Regulation, Fungal, Gene Deletion, Oxidative Stress, Acetic Acid, Gene Expression Profiling, Saccharomyces cerevisiae Proteins, Histone Acetyltransferases
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