Genetic characterization of tube and pelle, genes required for signaling between Toll and dorsal in the specification of the dorsal-ventral pattern of the Drosophila embryo.
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tube and pelle are two of the maternally transcribed genes required for dorsal-ventral patterning of the Drosophila embryo. Females homozygous for strong alleles of tube or pelle produce embryos that lack all ventral and lateral embryonic pattern elements. By analyzing the phenotypes caused by 24 pelle and 9 tube alleles, we have defined characteristic features of the two genes, including the extremely variable phenotypes of a number of tube alleles and the antimorphic character of a number of pelle alleles. Double mutant females carrying dominant ventralizing alleles of Toll and dorsalizing alleles of tube or pelle produce dorsalized embryos, suggesting that tube and pelle act downstream of the membrane protein Toll in the signaling pathway that defines the embryonic dorsal-ventral pattern. Both tube and pelle are also important zygotically for survival: at least 30% of the zygotes lacking either tube or pelle die before adult stages, while 90-95% of tube- pelle- double mutant zygotes die. We discuss the phenotypes of tube-pelle double mutants in the context of whether the two proteins interact directly.
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Downstream of Spatzle-mediated activation of Toll, intracellular signaling occurs through maternal factors including Weckle, Myd88, Tube, and Pelle, which function together to facilitate degradation of Cactus, releasing Dorsal from cytoplasmic retention.
“Downstream of the Spz-mediated activation of Toll, intracellular signaling occurs through the action of several maternal factors.These proteins, which include Weckle, Myd88, Tube, and Pelle, function together to facilitate the degradation of Cactus, a cytoplasmic tethering protein, thereby releasing Dorsal from cytoplasmic retention”
From Graded dorsal and differential gene regulation in the Drosophila embryo. (2009) · cites this paper as Hecht and Anderson 1993
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- ANDERSON, K. V., and C. NUSSLEIN-VOLHARD, 1986 Dorsal-group genes of Drosophila, pp. 174-194 in Gametogenesis and the Early Embryo, edited by J. GALL. Alan R. Liss, New York.
- HUDSON, K. L., 1989 Ph.D. Dissertation. University of California, Berkeley.
- IP, Y., R. KRAUT, M. LEVINE and C. RUSHLOW, 1991 The dorsal 607-6 16. 11 1-127. 269-279. Downloaded from https://academic.oup.com/genetics/article/135/2/405/6011248 by guest on 17 July 2024 morphogen is a sequence-specific DNA binding protein that interacts with a long-range repression element in Drosophila. Cell 64: 439-446.
- LETSOU, A,, S. ALEXANDER, K. ORTH and S. A. WASSERMAN, 199 1 Genetic and molecular characterization of tube, a Dro- sophila gene maternally required for embryonic dorsoventral polarity. Proc. Natl. Acad. Sci. USA 88: 810-814.
- LINDSLEY, D. L., and G. G. ZIMM, 1992 The Genome of Drosophila melanogaster. Academic Press, San Diego.
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- WIESCHAUS, E., and C. NUSSLEIN-VOLHARD, 1986 Looking at embryos, pp. 199-227 in Drosophila: A Practical Approach, edited by D. M. ROBERTS. IRL Press, Oxford. 1179-1 188. Communicating editor: T . SCH~JPBACH Downloaded from https://academic.oup.com/genetics/article/135/2/405/6011248 by guest on 17 July 2024
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Graded dorsal and differential gene regulation in the Drosophila embryo.
Reeves, G. T., & Stathopoulos, A. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000836 · Cited by 119 · see citing works
- Authors
- Hecht, P. M., & Anderson, K. V.
- Affiliations
- University of California, Berkeley (US)
- ORCID
- Anderson, K V
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-10-01
- Volume
- 135
- Issue
- 2
- Pages
- 405-417
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2187705722
- Cited by
- 80
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2021: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 5 · 2012: 3
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Genetics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
- Keywords
- Toll signaling, dorsoventral patterning, Drosophila embryo, maternal genes, zygotic lethality, genetic interactions
- MeSH terms
- Alleles, Animals, Drosophila, Embryo, Nonmammalian, Female, Genes, Dominant, Homozygote, Male, Phenotype, Recombination, Genetic, Transcription, Genetic, Signal Transduction, Mutagenesis
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