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Constructing confidence intervals for QTL location.
Abstract
We describe a method for constructing the confidence interval of the QTL location parameter. This method is developed in the local asymptotic framework, leading to a linear model at each position of the putative QTL. The idea is to construct a likelihood ratio test, using statistics whose asymptotic distribution does not depend on the nuisance parameters and in particular on the effect of the QTL. We show theoretical properties of the confidence interval built with this test, and compare it with the classical confidence interval using simulations. We show in particular, that our confidence interval has the correct probability of containing the true map location of the QTL, for almost all QTLs, whereas the classical confidence interval can be very biased for QTLs having small effect.
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Citations
Cited by
False Discovery Rate–Adjusted Multiple Confidence Intervals for Selected Parameters
Benjamini, Y., & Yekutieli, D. (2005) · Journal of the American Statistical Association · doi:10.1198/016214504000001907 · Cited by 671
QTL analysis in plants; where are we now?
Kearsey, M. J., & Farquhar, A. G. L. (1998) · Heredity · doi:10.1046/j.1365-2540.1998.00500.x · Cited by 492
Genetic Analysis of Inherited Hypertension in the Rat
Rapp, J. P. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.135 · Cited by 422
(2012) · Iowa State University Digital Repository (Iowa State University) · Cited by 8
Metadata
- Authors
- Mangin, B., Goffinet, B., & Rebaï, A.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-12-01
- Volume
- 138
- Issue
- 4
- Pages
- 1301-1308
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2116613035
- Cited by
- 160
- References
- 0
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Constructing confidence intervals for QTL location. https://app.cochat.ai/papers/10.1093/genetics/138.4.1301
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- Mangin, B., Goffinet, B., & Rebaï, A. (1994). Constructing confidence intervals for QTL location. Genetics. https://doi.org/10.1093/genetics/138.4.1301
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