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Epistasis and its contribution to genetic variance components.
Open accessAbstract
We present a new parameterization of physiological epistasis that allows the measurement of epistasis separate from its effects on the interaction (epistatic) genetic variance component. Epistasis is the deviation of two-locus genotypic values from the sum of the contributing single-locus genotypic values. This parameterization leads to statistical tests for epistasis given estimates of two-locus genotypic values such as can be obtained from quantitative trait locus studies. The contributions of epistasis to the additive, dominance and interaction genetic variances are specified. Epistasis can make substantial contributions to each of these variance components. This parameterization of epistasis allows general consideration of the role of epistasis in evolution by defining its contribution to the additive genetic variance.
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Cites
Genetic revolutions, founder effects, and speciation
Barton, N. H., & Charlesworth, B. (1984) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.es.15.110184.001025 · Cited by 681
Linkage and selection: Two locus symmetric viability model
Karlin, S., & Feldman, M. W. (1970) · Theoretical Population Biology · doi:10.1016/0040-5809(70)90041-9 · Cited by 174
Cited by
Detecting gene–gene interactions that underlie human diseases
Cordell, H. J. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2579 · Cited by 1,350
The Genetic Architecture of Quantitative Traits
Mackay, T. F. C. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.090633 · Cited by 1,106
Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans
Cordell, H. J. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.20.2463 · Cited by 1,084
Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits
Hill, W. G., Goddard, M. E., & Visscher, P. M. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000008 · Cited by 1,039
Uncovering cryptic genetic variation
Gibson, G., & Dworkin, I. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1426 · Cited by 546
Metadata
- Authors
- Cheverud, J. M., & Routman, E. J.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-03-01
- Volume
- 139
- Issue
- 3
- Pages
- 1455-1461
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2157308673
- Cited by
- 518
- References
- 2
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cheverud, J. M., & Routman, E. J. (1995). Epistasis and its contribution to genetic variance components. Genetics. https://doi.org/10.1093/genetics/139.3.1455
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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