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Cited by 1,311

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Distinguishing Migration From Isolation: A Markov Chain Monte Carlo Approach

Nielsen, Rasmus, Wakeley, John·2001·Genetics

Abstract

A Markov chain Monte Carlo method for estimating the relative effects of migration and isolation on genetic diversity in a pair of populations from DNA sequence data is developed and tested using simulations. The two populations are assumed to be descended from a panmictic ancestral population at some time in the past and may (or may not) after that be connected by migration. The use of a Markov chain Monte Carlo method allows the joint estimation of multiple demographic parameters in either a Bayesian or a likelihood framework. The parameters estimated include the migration rate for each population, the time since the two populations diverged from a common ancestral population, and the relative size of each of the two current populations and of the common ancestral population. The results show that even a single nonrecombining genetic locus can provide substantial power to test the hypothesis of no ongoing migration and/or to test models of symmetric migration between the two populations. The use of the method is illustrated in an application to mitochondrial DNA sequence data from a fish species: the threespine stickleback (Gasterosteus aculeatus).

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Metadata

Authors
Nielsen, R., & Wakeley, J.
Venue
Genetics
Published
2001-06-01
Volume
158
Issue
2
Pages
885-896
ISSN
  • 0016-6731 (ISSN-L)
  • 1943-2631
OpenAlex
W1934545424
Cited by
1,311
References
31
FWCI
11.73
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Distinguishing Migration From Isolation: A Markov Chain Monte Carlo Approach. https://app.cochat.ai/papers/10.1093/genetics/158.2.885
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Nielsen, R., & Wakeley, J. (2001). Distinguishing Migration From Isolation: A Markov Chain Monte Carlo Approach. Genetics. https://doi.org/10.1093/genetics/158.2.885

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