Cited by 84Genetic diversity and population structureEvolution and Genetic DynamicsMarine Bivalve and Aquaculture Studies

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POPULATION GENETICS OF MARINE PELECYPODS. III. EPISTASIS BETWEEN FUNCTIONALLY RELATED ISOENZYMES OF MYTILUS EDULIS

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Mitton, Jeffry B, Koehn, Richard K·1973·Genetics

DOI 10.1093/genetics/73.3.487

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Abstract

The distribution of interlocus genotypic combinations was examined in Mytilus edulis for interdependence between two loci synthesizing functionally related isoenzymes. There is significant dependence between the Leucine Aminopeptidase and Aminopeptidase loci, which we attribute to epistasis, since the magnitude of dependency varies with age. Furthermore, dependency varies in magnitude with position in the intertidal zone from which samples were taken, suggesting that epistasis is a function of the combination of certain non-homologous alleles as well as of the environmental circumstance in which the combinations occur.

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Hedrick, P. W., Jain, S. K., & Holden, L. R. (1978) · Springer eBooks · doi:10.1007/978-1-4615-6956-5_3 · Cited by 230
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Skibinski, D. O. F., Beardmore, J. A., & Cross, T. F. (1983) · Biological Journal of the Linnean Society · doi:10.1111/j.1095-8312.1983.tb00782.x · Cited by 226
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Buroker, N. E. (1983) · Marine Biology · doi:10.1007/bf00392635 · Cited by 180
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Black, W. C., & Krafsur, E. S. (1985) · Theoretical and Applied Genetics · doi:10.1007/bf00305981 · Cited by 169
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Daguin‐Thiébaut, C., Bonhomme, F., & Borsa, P. (2001) · Heredity · doi:10.1046/j.1365-2540.2001.00832.x · Cited by 116
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Levinton, J. S., & Suchanek, T. H. (1978) · Marine Biology · doi:10.1007/bf00455031 · Cited by 93
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Ahmad, M., Skibinski, D. O. F., & Beardmore, J. A. (1977) · Biochemical Genetics · doi:10.1007/bf00483980 · Cited by 91
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Ewens, W. J., & Feldman, M. W. (1976) · Elsevier eBooks · doi:10.1016/b978-0-12-398560-6.50018-3 · Cited by 42
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Spatial structure of two-locus genotypes under isolation by distance.
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Colgan, D. J. (1981) · Heredity · doi:10.1038/hdy.1981.27 · Cited by 19
Linkage disequilibrium in natural and experimental populations of Drosophila melanogaster.
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Self-citation
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Authors: Mitton, J. B., & Koehn, R. K.
Affiliations: Stony Brook University (US)
ORCID: Mitton, Jeffry B
Venue: Genetics
Publisher: Oxford University Press (OUP)
Published: 1973-03-01
Volume: 73
Issue: 3
Pages: 487-496
ISSN: 0016-6731 (ISSN-L)
1943-2631
DOI: 10.1093/genetics/73.3.487
OpenAlex: W1933236899
Cited by: 84
References: 0
Citations by year: 2024: 1 · 2021: 1 · 2019: 1
FWCI: 4.07
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Genetics (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Marine Bivalve and Aquaculture Studies
Keywords: epistasis, Mytilus edulis, isozymes, leucine aminopeptidase, aminopeptidase, intertidal zone, age effects
MeSH terms: Alleles, Aminopeptidases, Animals, Genetics, Population, Genotype, Isoenzymes, Leucyl Aminopeptidase, Polymorphism, Genetic, Bivalvia

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POPULATION GENETICS OF MARINE PELECYPODS. III. EPISTASIS BETWEEN FUNCTIONALLY RELATED ISOENZYMES OF MYTILUS EDULIS

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