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THE HOMOZYGOSITY TEST OF NEUTRALITY
Open accessAbstract
An earlier paper showed that the homozygosity (of a population or sample) was a good statistic for testing departures from selective neutrality in the direction of heterozygote advantage or disadvantage. It is here shown that homozygosity is also influenced by the presence of deleterious alleles and by other departures from neutrality, but at a lower order of magnitude of effect if the selection coefficients are of the same small order of magnitude. Tables are provided for the significance points and moments of the homozygosity, under the null hypothesis of neutrality.
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Citations
Cited by
A Test of Neutral Molecular Evolution Based on Nucleotide Data
Hudson, R. R., Kreitman, M., & Aguadé, M. (1987) · Genetics · doi:10.1093/genetics/116.1.153 · Cited by 1,767
Properties of a neutral allele model with intragenic recombination
Hudson, R. R. (1983) · Theoretical Population Biology · doi:10.1016/0040-5809(83)90013-8 · Cited by 816
Detecting Natural Selection in Genomic Data
Vitti, J. J., Grossman, S. R., & Sabeti, P. C. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133526 · Cited by 694
Stinchcombe, J. R., & Hoekstra, H. E. (2008) · Heredity · doi:10.1038/sj.hdy.6800937 · Cited by 622
The hitchhiking effect on the site frequency spectrum of DNA polymorphisms
Braverman, J. M., Hudson, R. R., Kaplan, N. L., Langley, C. H., & Stephan, W. (1995) · Genetics · doi:10.1093/genetics/140.2.783 · Cited by 601
Metadata
- Authors
- Watterson, G. A.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1978-02-01
- Volume
- 88
- Issue
- 2
- Pages
- 405-417
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2101248726
- Cited by
- 682
- References
- 0
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Watterson, G. A. (1978). THE HOMOZYGOSITY TEST OF NEUTRALITY. Genetics. https://doi.org/10.1093/genetics/88.2.405
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
