Cited by 71Evolution and Genetic DynamicsGenetic diversity and population structureGenetic Associations and Epidemiology

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LINKAGE DISEQUILIBRIUM IN A FINITE POPULATION THAT IS PARTIALLY SELFING

Golding, G B, Strobeck, C·1980·Genetics

DOI 10.1093/genetics/94.3.777

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Abstract

The linkage disequilibrium expected in a finite, partially selfing population is analyzed, assuming the infinite allele model. Formulas for the expected sum of squares of the linkage disequilibria and the squared standard linkage disequilibrium are derived from the equilibrium values of sixteen inbreeding coefficients required to describe the behavior of the system. These formulas are identical to those obtained with random mating if the effective population size Ne = (l—½S)N and the effective recombination value re = (l-S)r/(l-½S), where S is the proportion of selfing, are substituted for the population size and the recombination value, Therefore, the effect of partial selfing at equilibrium is to reduce the population size by a factor 1 — ½S and the recombination value by a factor (l-S)/(l—½S).

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Authors: Golding, G. B., & Strobeck, C.
Affiliations: University of Alberta (CA)
ORCID: Golding, G B
Strobeck, C
Venue: Genetics
Publisher: Oxford University Press (OUP)
Published: 1980-03-01
Volume: 94
Issue: 3
Pages: 777-789
ISSN: 0016-6731 (ISSN-L)
1943-2631
DOI: 10.1093/genetics/94.3.777
OpenAlex: W1864724810
Cited by: 71
References: 13
Citations by year: 2026: 1 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 3 · 2019: 4 · 2018: 1 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 3
FWCI: 1.27
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: linkage disequilibrium, partial selfing, finite population, inbreeding coefficient, infinite allele model, effective population size, panmixia

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LINKAGE DISEQUILIBRIUM IN A FINITE POPULATION THAT IS PARTIALLY SELFING

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