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AGENTS THAT CAUSE A HIGH FREQUENCY OF GENETIC CHANGE FROM [psi +] TO [psi -] IN SACCHAROMYCES CEREVISIAE
Open accessAbstract
The [psi] factor of yeast is cytoplasmically inherited. Singh, Helms and Sherman (1979) reported that high concentrations of KCl and of ethylene glycol induce the genetic change from [psi +] to [psi -]. In this study, the following agents have been shown to induce the same genetic change: guanidine hydrochloride at 1 mm, dimethyl sulfoxide at 2.5% v/v and ethanol or methanol at 10% v/v. It is likely that a number of other agents also cause the change, namely 2 m glycerol, m succinate, m glutamate and m MgCl2. Most of these agents induce the change at very high frequencies; with some, the frequency is 100%. Although the observed phenotypic change can also occur as a result of chromosomal gene mutation, no changes of this type were identified. Some of the agents also cause mutation from [rho +] to [rho -] and from killer to sensitive.
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Citations
Cited by
Prions Affect the Appearance of Other Prions
Derkatch, I. L., Bradley, M. E., Hong, J. Y., & Liebman, S. W. (2001) · Cell · doi:10.1016/s0092-8674(01)00427-5 · Cited by 559
Hieter, P. (1985) · Cell · doi:10.1016/0092-8674(85)90152-7 · Cited by 469
Prion-Inducing Domain of Yeast Ure2p and Protease Resistance of Ure2p in Prion-Containing Cells
Masison, D. C., & Wickner, R. B. (1995) · Science · doi:10.1126/science.270.5233.93 · Cited by 347
Multiple Gln/Asn-Rich Prion Domains Confer Susceptibility to Induction of the Yeast [PSI] Prion
Osherovich, L. Z., & Weissman, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00440-8 · Cited by 301
Prion Switching in Response to Environmental Stress
Tyedmers, J., Madariaga, M. L., & Lindquist, S. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060294 · Cited by 263
Metadata
- Authors
- Tuite, M. F., Mundy, C. R., & Cox, B. S.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1981-08-01
- Volume
- 98
- Issue
- 4
- Pages
- 691-711
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W1857855090
- Cited by
- 295
- References
- 0
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: AGENTS THAT CAUSE A HIGH FREQUENCY OF GENETIC CHANGE FROM [psi +] TO [psi -] IN SACCHAROMYCES CEREVISIAE. https://app.cochat.ai/papers/10.1093/genetics/98.4.691
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- Tuite, M. F., Mundy, C. R., & Cox, B. S. (1981). AGENTS THAT CAUSE A HIGH FREQUENCY OF GENETIC CHANGE FROM [psi +] TO [psi -] IN SACCHAROMYCES CEREVISIAE. Genetics. https://doi.org/10.1093/genetics/98.4.691
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
