Protein Homeostasis and Aging: Taking Care of Proteins From the Cradle to the Grave
Open accessAbstract
All cells count on precise mechanisms that regulate protein homeostasis to maintain a stable and functional proteome. Alterations in these fine-tuned mechanisms underlie the pathogenesis of severe human diseases including, among others, common neurodegenerative disorders such as Alzheimer's or Parkinson's disease. A progressive deterioration in the ability of cells to preserve the stability of their proteome occurs with age, even in the absence of disease, and it likely contributes to different aspects of "normal" aging. A group of experts in different aspects of the biology of aging met recently to discuss the implications of altered protein homeostasis in aging, the current gaps in our understanding of the mechanisms responsible for proteome maintenance, and future opportunities for discovery in this area. We summarize here some of the key topics and main outcomes of the discussions.
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The association between age and protein misfolding diseases suggests that aged cells may be more prone to form and accumulate misfolded protein aggregates.
“This association suggests that aged cells may be more prone to form and accumulate misfolded protein aggregates71,73.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [73]
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References 20 · Cited by 151
Research works printed but not linked: 2
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- Authors
- Morimoto, R. I., & Cuervo, A. M.
- Affiliations
- Albert Einstein College of Medicine (US)
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-02-01
- Volume
- 64A
- Issue
- 2
- Pages
- 167-170
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC2655025
- OpenAlex
- W2137275982
- Cited by
- 151
- References
- 20
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 8 · 2015: 13 · 2014: 10 · 2013: 12 · 2012: 11
- FWCI
- 6.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- proteostasis, aging, protein stability, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Homeostasis, Humans, Longevity, Parkinson Disease, Proteins, Risk Factors, Cellular Senescence, Protein Folding, Oxidative Stress, Neurodegenerative Diseases, Proteasome Endopeptidase Complex
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