Cited by 180Muscle Physiology and DisordersCardiovascular and exercise physiologyMuscle metabolism and nutrition

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Myostatin Inhibition Enhances the Effects of Exercise on Performance and Metabolic Outcomes in Aged Mice

LeBrasseur, N. K., Schelhorn, T. M., Bernardo, B. L., Cosgrove, P. G., Loria, P. M., Brown, T. A.·2009·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Abstract

The objective of this study was to examine the effects of short-term exercise training, myostatin inhibition (PF-354), and exercise+PF-354, all relative to a vehicle control, on performance and metabolic measures in 24-month-old mice. At study termination, PF-354-treated mice exhibited significantly greater muscle weights. Performance measures revealed that exercise+PF-354 increased treadmill running time and distance to exhaustion (more than twofold) and increased habitual activity. Measures of strength were not different; however, all treatment groups demonstrated more than 30% reductions in muscle fatigue. Metabolic measures showed that basal metabolic rates were higher in PF-354- and exercise+PF-354-treated mice, and exercise and exercise+PF-354 groups exhibited significantly greater insulin sensitivity. PF-354 was associated with decreased Smad3 phosphorylation and increased peroxisome proliferator-activated receptor gamma coactivator-1alpha expression and, similar to exercise, decreased MuRF-1. The data suggest that the combination of exercise training and myostatin blockade may significantly improve physical function and whole-body metabolism in older individuals.

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  1. 2006, 39, 845
  2. 2009, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 64, 209

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Metadata

Authors
LeBrasseur, N. K., Schelhorn, T. M., Bernardo, B. L., Cosgrove, P. G., Loria, P. M., & Brown, T. A.
Affiliations
Pfizer (United States) (US)
Venue
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Published
2009-05-29
Volume
64A
Issue
9
Pages
940-948
ISSN
  • 1079-5006 (ISSN-L)
  • 1758-535X
OpenAlex
W2165995731
Cited by
180
References
42
Citations by year
2026: 1 · 2025: 5 · 2024: 10 · 2023: 8 · 2022: 12 · 2021: 7 · 2020: 9 · 2019: 9 · 2018: 12 · 2017: 14 · 2016: 17 · 2015: 13 · 2014: 17 · 2013: 16 · 2012: 10
FWCI
4.03
Type
journal article
Language
en
Open access
closed
Locations
  • The Journals of Gerontology Series A (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords
myostatin inhibition, exercise training, aging, muscle atrophy, muscle fatigue, endurance performance, insulin sensitivity, basal metabolic rate, Smad3 phosphorylation, PGC-1α, MuRF1, muscle strength, treadmill running
MeSH terms
Aging, Animals, Energy Metabolism, Insulin Resistance, Male, Mice, Inbred C57BL, Phosphorylation, Physical Conditioning, Animal, Muscle, Skeletal, Mice, Smad3 Protein, Muscle Strength, Myostatin

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