Age-related Changes in Parathyroid Hormone and 25 Hydroxycholecalciferol Levels
Abstract
Serum parathyroid hormone and 25 hydroxyvitamin D were measured in 124 normal subjects aged from 20 to 90 years. There was a significant progressive increase in serum parathyroid levels with age associated with a progressive decrease in total serum calcium. After the sixth decade there was a significant reduction of 25 hydroxyvitamin D serum levels. In each age group, there were no significant differences between men and women in all parameters measured. In normal elderly subjects there is an age-related decline of calcium absorption associated with reduced calcium intake and sun exposure leading to secondary hyperparathyroidism. These results emphasize the importance of calcium and vitamin D supplementation in elderly European population, not only in long-stay patients but in ambulatory normal people after 60 years.
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Aging populations, including post-menopausal women, have shown other physiological changes related to the systems in the model, such as a blunted response to ACE inhibitors, lower GFR, decreased intestinal calcium absorption, lower vitamin D levels, and higher PTH levels.
“For example, aging populations have shown a blunted response to ACE inhibitors, have a lower GFR, decreased intestinal calcium absorption, lower vitamin D levels, and higher PTH levels [57-59].”
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Meier, D. E., Orwoll, E. S., Keenan, E. J., & Fagerstrom, R. M. (1987) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1987.tb02308.x · Cited by 131 · see citing works
Landin-Wilhelmsen, K., Wilhelmsen, L., Lappas, G., Ros�n, T., Lindstedt, G., Lundberg, P. A., Wilske, J., & Bengtsson, B. �. (1995) · Calcified Tissue International · doi:10.1007/bf00296339 · Cited by 90 · see citing works
Stadt, M. M., & Layton, A. T. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.01.651663
- Authors
- Chapuy, M.-C., Durr, F., & Chapuy, P.
- Affiliations
- Inserm (FR)
- Hospices Civils de Lyon (FR)
- Venue
- Journal of Gerontology
- Publisher
- Oxford University Press (OUP)
- Published
- 1983-01-01
- Volume
- 38
- Issue
- 1
- Pages
- 19-22
- ISSN
- 0022-1422 (ISSN-L)
- OpenAlex
- W2060607320
- Cited by
- 132
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- parathyroid hormone, 25-hydroxyvitamin D, aging, serum calcium, secondary hyperparathyroidism, calcium absorption, vitamin D supplementation, older adults, sex differences
- MeSH terms
- Adult, Aged, Aging, Calcium, Ergocalciferols, Female, Humans, Hyperparathyroidism, Male, Middle Aged, Parathyroid Hormone, 25-Hydroxyvitamin D 2, Fractures, Bone
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