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Sleep Disturbances in Patients With Mild-Stage Alzheimer's Disease
Abstract
We examined the ability of sleep/wake measures to discriminate 45 control subjects from 44 mild Alzheimer's disease (AD) patients. Sleep fragmentation was observed as indicated by significant increases in time awake (37-52%) and number of awakenings (31-36%) during the night as compared to controls. Further, slow wave sleep (SWS) was significantly reduced (22%) in AD patients relative to controls. These findings are consistent with our earlier observations of increased wakefulness and decreased SWS in mild-moderate, moderate-severe, and severe stage AD patients. However, when we used these sleep/wake stage measures in discriminant analyses to classify the current AD subjects vs control subjects, the analyses failed to confirm our earlier high classification rate (90%). The present groups were discriminated at overall classification rates of only 63-67%. We conclude that while sleep/wake patterns are significantly disturbed in AD, this phenomenon is not diagnostically useful for discrimination of mild stage AD.
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“in patients with AD, sleep disruptions tend to begin after diagnosis261”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [261]
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Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
Wulff, K., Gatti, S., Wettstein, J. G., & Foster, R. G. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2868 · Cited by 1,055
Rhythms of life: circadian disruption and brain disorders across the lifespan
Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713
Sleep, Cognitive impairment, and Alzheimer's disease: a systematic review and meta-analysis
Bubu, O. M., Brannick, M., Mortimer, J., Umasabor-Bubu, O., Sebastião, Y. V., Wen, Y., Schwartz, S., Borenstein, A. R., Wu, Y., Morgan, D., et al. (2017) · Sleep · doi:10.1093/sleep/zsw032 · Cited by 673
Need-driven dementia-compromised behavior. An alternative view of disruptive behavior
Algase, D. L., Beck, C., Kolanowski, A., Whall, A., Berent, S., Richards, K., & Beattie, E. (1996) · American Journal of Alzheimer's Disease · doi:10.1177/153331759601100603 · Cited by 628
Wang, C., & Holtzman, D. M. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-019-0478-5 · Cited by 615
Metadata
- Authors
- Vitiello, M. V., Prinz, P. N., Williams, D. E., Frommlet, M. S., & Ries, R. K.
- Affiliations
- University of Washington (US)
- Venue
- Journal of Gerontology
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-07-01
- Volume
- 45
- Issue
- 4
- Pages
- M131-M138
- ISSN
- 0022-1422 (ISSN-L)
- OpenAlex
- W2121766792
- Cited by
- 223
- References
- 0
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 7 · 2023: 15 · 2022: 11 · 2021: 12 · 2020: 11 · 2019: 13 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 5 · 2014: 8 · 2013: 4 · 2012: 10
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh045186-03, 5r23ag004348-03)
- National Institute on Aging (AG04348)
- National Institute of Mental Health (MH-45186, MH33688)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- Alzheimer's disease, mild Alzheimer's disease, sleep disorders, sleep fragmentation, slow-wave sleep, wakefulness, nocturnal awakenings, diagnostic value, discriminant analysis
- MeSH terms
- Aged, Alzheimer Disease, Female, Humans, Male, Psychiatric Status Rating Scales, Sleep Wake Disorders, Sleep Stages
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