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Glycosylation of recombinant protein therapeutics: control and functional implications
Abstract
The discovery, development, production and clinical application of recombinant glycoproteins for therapeutic administration in humans has been, and continues to be, an area of intensive scientific and medical effort. This effort has engendered considerable interest in the biological and therapeutic implications of post-translational modifications, particularly the most elaborated and sophisticated of these, protein glycosylation. As a result, numerous studies have appeared in the literature, especially within the past few years, which have greatly expanded our understanding of the biology of protein glycosylation. This review seeks to summarize these studies, illustrating that protein glycosylation, by modulating numerous biological attributes, is of central import in defining the utility of recombinant therapeutics.
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Citations
Cited by
Protein glycosylation: Structural and functional aspects
LIS, H., & SHARON, N. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18347.x · Cited by 833
How N-linked oligosaccharides affect glycoprotein folding in the endoplasmic reticulum.
Helenius, A. (1994) · Molecular Biology of the Cell · doi:10.1091/mbc.5.3.253 · Cited by 623
Davis, B. G. (2002) · Chemical Reviews · doi:10.1021/cr0004310 · Cited by 521
Huddleston, M. J., Bean, M. F., & Carr, S. A. (1993) · Analytical Chemistry · doi:10.1021/ac00055a009 · Cited by 395
Carr, S. A., Huddleston, M. J., & Bean, M. F. (1993) · Protein Science · doi:10.1002/pro.5560020207 · Cited by 284
Metadata
- Authors
- Cumming, D. A.
- Venue
- Glycobiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1991
- Volume
- 1
- Issue
- 2
- Pages
- 115-130
- ISSN
- 0959-6658 (ISSN-L)
- 1460-2423
- OpenAlex
- W2000540313
- Cited by
- 207
- References
- 0
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cumming, D. A. (1991). Glycosylation of recombinant protein therapeutics: control and functional implications. Glycobiology. https://doi.org/10.1093/glycob/1.2.115
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
