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A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human
Abstract
A new gene, designated Smcx, was cloned from the mouse X chromosome by its homology to the Y located gene Smcy. Using direct in situ hybridisation Smcx was mapped to the distal end of the mouse X chromosome (XF2-XF4) and its human homologue, SMCX, was mapped to proximal Xp (Xp11.1-Xp11.2). Further meiotic mapping in the mouse placed Smcx in the Plp-Pdha1 interval. As Smcx/SMCX have widely expressed homologues on the Y chromosome, they appeared good candidates for genes that escape X-inactivation. In the human we show this to be the case as SMCX is expressed in hamster-human hybrids containing either an active or inactive human X chromosome. Two alleles of Smcx were found to be expressed in T(16;X)16H female mice despite the intact X chromosome being inactive in all cells. This indicates that Smcx is also not subject to X-inactivation and provides the first example of a gene that is expressed from inactive and active X chromosomes in the mouse.
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Cited by
Requirement for Xist in X chromosome inactivation
Penny, G. D., Kay, G. F., Sheardown, S. A., Rastan, S., & Brockdorff, N. (1996) · Nature · doi:10.1038/379131a0 · Cited by 1,205
Four Evolutionary Strata on the Human X Chromosome
Lahn, B. T., & Page, D. C. (1999) · Science · doi:10.1126/science.286.5441.964 · Cited by 990
Functional Coherence of the Human Y Chromosome
Lahn, B. T., & Page, D. C. (1997) · Science · doi:10.1126/science.278.5338.675 · Cited by 803
RBP2 Belongs to a Family of Demethylases, Specific for Tri-and Dimethylated Lysine 4 on Histone 3
Christensen, J., Agger, K., Cloos, P. A. C., Pasini, D., Rose, S., Sennels, L., Rappsilber, J., Hansen, K. H., Salcini, A. E., & Helin, K. (2007) · Cell · doi:10.1016/j.cell.2007.02.003 · Cited by 553
The origin and function of the mammalian Y chromosome and Y‐borne genes – an evolving understanding
Graves, J. A. M. (1995) · BioEssays · doi:10.1002/bies.950170407 · Cited by 379
Metadata
- Authors
- Agulnik, A. I., Mitchell, M. J., Mattei, M.-G., Borsani, G., Avner, P. A., Lerner, J. L., & Bishop, C. E.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1994
- Volume
- 3
- Issue
- 6
- Pages
- 879-884
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2093905111
- Cited by
- 164
- References
- 0
- FWCI
- 8.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Agulnik, A. I., Mitchell, M. J., Mattei, M.-G., Borsani, G., Avner, P. A., Lerner, J. L., & Bishop, C. E. (1994). A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human. Human Molecular Genetics. https://doi.org/10.1093/hmg/3.6.879
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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