Genetics of multiple sclerosis [published erratum appears in Hum Mol Genet 1997 Nov;6(12):2189]
Abstract
Multiple Sclerosis (MS) is a common chronic central nervous system disease in young adults. Relative familial risk appears to be determined largely by genes while population risk is strongly influenced by environmental factors. This is supported by genetic epidemiological studies which also suggest an oligogenic inheritance of susceptibility. The HLA DRB1*1501, DQA1*0102, DQB1 0602 haplotype is associated with the disease but HLA contributes only modestly to overall susceptibility. The results of three genomic searches are concordant with the genetic epidemiology and imply a number of genes with interacting effects will be found. Importantly, no single region has been identified with a major influence on familial risk.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Candidate gene studies in multiple sclerosis produced inconsistent findings.
“Candidate gene studies in cohorts of tens or hundreds of individuals at the loci encoding T‐cell receptor alpha12, 13 and beta14, 15 loci, the immunoglobulin heavy‐chain genes16, 17 and the gene for myelin basic protein,18, 19 among others, produced inconsistent findings.20, 21”
From Genome‐wide association studies of multiple sclerosis (2018) · cites this paper as [21]
Cites
Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029 · see citing works
Epidemiologic evidence for multiple sclerosis as an infection
Kurtzke, J. F. (1993) · Clinical Microbiology Reviews · doi:10.1128/cmr.6.4.382 · Cited by 472 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The burden of complex genetics in brain disorders
Uhl, G. R., & Grow, R. W. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.3.223 · Cited by 176 · see citing works
Genome‐wide association studies of multiple sclerosis
Cotsapas, C., & Mitrovic, M. (2018) · Clinical & Translational Immunology · doi:10.1002/cti2.1018 · Cited by 89 · see citing works
- Authors
- Dyment, D.
- Affiliations
- Western University (CA)
- Corresponding author
- Dyment, D.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-09-01
- Volume
- 6
- Issue
- 10
- Pages
- 1693-1698
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2116104996
- Cited by
- 152
- References
- 2
- Citations by year
- 2024: 1 · 2023: 4 · 2022: 4 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 5 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 7 · 2012: 2
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Molecular Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- multiple sclerosis, genetic susceptibility, HLA-DRB1*1501, HLA-DQA1*0102, HLA-DQB1*0602, HLA haplotypes, oligogenic inheritance, familial risk, environmental risk factors, genetic epidemiology, genome-wide search
- MeSH terms
- Adult, Chromosome Mapping, Chromosomes, Human, Disease Susceptibility, Diseases in Twins, Environment, Family, Genetic Markers, HLA-D Antigens, HLA-DQ Antigens, HLA-DR Antigens, Humans, Multiple Sclerosis, Risk Factors, HLA-DRB1 Chains, HLA-DQ alpha-Chains, HLA-DQ beta-Chains
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
