Chromosome painting: a useful art
Abstract
Chromosome 'painting' refers to the hybridization of fluorescently labeled chromosome-specific, composite probe pools to cytological preparations. Chromosome painting allows the visualization of individual chromosomes in metaphase or interphase cells and the identification of both numerical and structural chromosomal aberrations in human pathology with high sensitivity and specificity. In addition to human chromosome-specific probe pools, painting probes have become available for an increasing range of different species. They can be applied to cross-species comparisons as well as to the study of chromosomal rearrangements in animal models of human diseases. The simultaneous hybridization of multiple chromosome painting probes, each tagged with a specific fluorochrome or fluorochrome combination, has resulted in the differential color display of human (and mouse) chromosomes, i.e. color karyotyping. In this review, we will summarize recent developments of multicolor chromosome painting, describe applications in basic chromosome research and cytogenetic diagnostics, and discuss limitations and future directions.
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In cases of complex rearrangements, chromosomal painting can be laborious and requires confirmation.
“Also, it was reported that in cases of complex rearrangements chromosomal painting can be laborious and requires confirmation [22].”
From halSynteny: a fast, easy-to-use conserved synteny block construction method for multiple whole-genome alignments (2020) · cites this paper as [22]
Cites
Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting.
Jauch, A., Wienberg, J., Stanyon, R., Arnold, N., Tofanelli, S., Ishida, T., & Cremer, T. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.18.8611 · Cited by 310 · see citing works
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Krasheninnikova, K., Diekhans, M., Armstrong, J., Dievskii, A., Paten, B., & O'Brien, S. (2020) · GigaScience · doi:10.1093/gigascience/giaa047 · Cited by 30 · see citing works
Topological Approaches in Animal Comparative Genomics
Schultz, D. T., & Simakov, O. (2026) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-030424-084541 · Cited by 1 · see citing works
- Authors
- Ried, T.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Ried, T
- ORCID
- Ried, T
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-09-01
- Volume
- 7
- Issue
- 10
- Pages
- 1619-1626
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2098017335
- Cited by
- 154
- References
- 1
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 11 · 2022: 2 · 2021: 7 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 4 · 2015: 9 · 2014: 7 · 2013: 3 · 2012: 1
- FWCI
- 6.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Molecular Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- chromosome painting, chromosome-specific probes, chromosomal abnormalities, chromosomal rearrangements, animal models of human disease
- MeSH terms
- Animals, Chromosome Aberrations, Cytogenetics, Female, Genetics, Medical, Humans, Karyotyping, Male, Neoplasms, Species Specificity, Translocation, Genetic, Chromosome Painting, Mice
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